PMID: 6159928Nov 3, 1980Paper

Alpha-adrenergic inhibition of cyclic AMP accumulation in hamster adipocytes. Similarity of receptor with alpha-2 adrenergic receptors

Biochimica Et Biophysica Acta
R J SchimmelK K McMahon

Abstract

The present communication shows the effects of several alpha-adrenergic agonists and antagonists on cyclic AMP levels in hamster epididymal adipocytes. In response to ACTH (30 mU/ml) in combination with 1-methyl-3-isobutylxanthine (0.10 mM) or adenosine deaminase (1.0 micrograms/ml), cyclic AMP levels increased to a maximum by 10 min and this level was maintained for another 20 min. Elevated cyclic AMP levels were partially suppressed by the alpha-adrenergic agents clonidine, methoxamine, methyl norepinephrine and phenylephrine. The lowest effective concentration of each of these agonists required to suppress cyclic AMP levels was 10 nM clonidine; 3 microM methoxamine; 10 microM methyl norepinephrine; 10 microM phenylephrine. Clonidine and methoxamine suppressed cyclic AMP levels by nearly 65% while phenylephrine and methyl norepinephrine caused only a 30% decline. Studies of the relative potencies of alpha-adrenergic blocking drugs on prevention of the inhibitor effect of clonidine on cyclic AMP levels disclosed that phentolamine and yohimbine were more potent blockers of clonidine action than phenoxybenzamine and prazosin. The rank order of potencies of agonists at causing suppression of cyclic AMP levels and the rank order o...Continue Reading

References

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
May 1, 1977·British Journal of Pharmacology·J C DoxeyJ M Walker
Sep 1, 1977·Life Sciences·S Berthelsen, W A Pettinger
Apr 15, 1979·Biochemical Pharmacology·C L WoodR J Lefkowitz
Feb 28, 1977·Biochimica Et Biophysica Acta·C Rosak, K J Hittelman
May 7, 1979·Life Sciences·B B HoffmanR J Lefkowitz
Jul 1, 1979·Canadian Journal of Biochemistry·N Bégin-HeickJ Sigouin
Jul 1, 1972·The Biochemical Journal·J M Stein, C N Hales
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke
Jul 1, 1974·Biochemical Pharmacology·S Z Langer

❮ Previous
Next ❯

Citations

Nov 21, 1989·European Journal of Pharmacology·J S Saulnier-BlacheM Lafontan
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C CarpeneM Lafontan
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H J Mersmann
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T B Ng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.