PMID: 6409081Mar 15, 1983Paper

alpha-adrenergic stimulation of respiration in isolated rat hepatocytes

The Biochemical Journal
A Binet, M Claret

Abstract

1. The alpha-adrenergic agonists noradrenaline (in the presence of beta-blocker) and phenylephrine cause a transient stimulation of the respiration in isolated rat hepatocytes. After a lag period of 12s, this activation first attains its maximal value (+24%) for about 1 min and then falls to a sustained value (+15%). The effect is blocked by the alpha-antagonists phenoxybenzamine and phentolamine. It is dose-dependent, with an half-maximal stimulation by 16 nM-noradrenaline, which is similar to that found for other cell responses to the hormone. 2. Vasopressin and ATP, which in common with alpha-agonists are believed to increase intracellular [Ca2+], induce similar activation in the respiration rate. 3. The alpha-adrenergic-mediated respiration depends on extracellular Ca2+. The activation is decreased or abolished when extracellular [Ca2+] is decreased by adding EGTA, or when the Ca2+ antagonists Mn2+ and La3+ are present in the incubation medium. 4. It is suggested that the activation of the mitochondrial respiration rate results from the increase in cytosolic Ca2+ concentration, presumably via Ca2+ influx or Ca2+ release from the plasma membrane or endoplasmic reticulum.

Citations

Mar 3, 1986·European Journal of Biochemistry·W M TaylorF L Bygrave
May 1, 1987·Biological Reviews of the Cambridge Philosophical Society·M D Brand, M P Murphy
Dec 1, 1990·Biochemical Pharmacology·E MezeyB E Akinshola
Dec 24, 2010·The Journal of Experimental Biology·Barbara Cannon, Jan Nedergaard
Dec 16, 1993·Biochimica Et Biophysica Acta·E UrcelayR Parrilla
Jan 1, 1991·The International Journal of Biochemistry·R Moreno-Sánchez, M E Torres-Márquez
Mar 1, 1986·Archives of Biochemistry and Biophysics·V Bobyleva-GuarrieroH A Lardy
Sep 1, 1988·Archives of Biochemistry and Biophysics·C González-ManchónR Parrilla

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