PMID: 6103744Jul 7, 1980Paper

Alpha-adrenoceptive influences on the control of the sleep-waking cycle in the cat

Brain Research
A Leppävuori, P T Putkonen

Abstract

Polygraphic 16 h sleep recording were carried out in 35 adult cats following i.p. injections of various alpha-adrenoceptors agonists, antagonists and their combinations. The direct alpha-agonists, clonidine (CLO 0.005, 0.01 and 0.02 mg/kg) and xylazine (XYL 0.5, 1 and 2 mg/kg), dose-dependently decreased paradoxical sleep (PS) and deep slow wave sleep (S2), with a respective increase mainly in drowsy waking (D). alpha-Methyldopa, precursor of the potent alpha-agonist, alpha-m-noradrenaline (alpha-m-NA) suppressed PS, with little effect on other vigilance stages. Of the alpha-antagonists only phentolamine (PHE 10 and 20 mg/kg) increased significantly the 16 h mean of PS. Thymoxamine (THY 5 mg/kg) gave a modest, temporary increment in PS between 4 and 8 h after the injection, but the effect diminished with 10 mg/kg THY. Yohimbine (YOH 2 mg/kg) induced an early increment in aroused waking (A). Tolazoline (TOL 6 mg/kg) and THY (5 and 10 mg/kg) increased D in the first 4 h epoch. Phenoxybenzamine (PBZ 10 mg/kg) significantly decreased the 16 h mean of S2 and PS. PHE antagonized the PS suppressing effect of CLO (0.01 mg/kg) already at the dose of 5 mg/kg and with 10 and 20 mg/kg its PS increasing character prevailed. TOL (6 mg/kg) an...Continue Reading

References

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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·W P Koella
Jan 1, 1989·European Journal of Clinical Pharmacology·A N NicholsonC Turner
Dec 15, 1982·Experientia·W P Koella
Jun 1, 1985·Electroencephalography and Clinical Neurophysiology·O Kanno, P Clarenbach
Oct 1, 1986·Electroencephalography and Clinical Neurophysiology·A Caballero, I De Andrés
Aug 8, 1980·European Journal of Pharmacology·I HilakiviP T Putkonen
Jul 30, 1982·European Journal of Pharmacology·W B PickworthV N Gupta
Mar 2, 1984·European Journal of Pharmacology·S Kafi-De St HilaireJ M Gaillard
Mar 1, 1984·Physiology & Behavior·C R Gordon, P Lavie
Sep 1, 1982·Pharmacology, Biochemistry, and Behavior·M GrafG A Schoenenberger
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·J P Mäkelä, I T Hilakivi
Aug 1, 1983·Behavioural Brain Research·C M Sinton, M Jouvet
Apr 1, 1986·Brain Research Bulletin·V Mohan KumarB Singh
Dec 15, 2010·PloS One·Tiago L RibeiroSidarta Ribeiro
May 12, 2009·Neuroscience and Biobehavioral Reviews·Florent G RevelJean-Luc Moreau
Jul 9, 2009·European Journal of Oral Sciences·Bengt GötrickGunnar Tobin
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·G W VogelA Hennessey
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·G VogelD Kors
Dec 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·D StenbergM V Miettinen
Mar 1, 1987·Pharmacology & Toxicology·I HilakiviA Shvaloff
Jan 1, 1983·British Journal of Clinical Pharmacology·J M Gaillard
Oct 1, 1981·Annals of Neurology·A S FoutzW C Dement

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