Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Louis-Philippe RicherJ A Armour

Abstract

Our objective was to determine whether neuronally induced atrial arrhythmias can be modified by alpha-adrenergic receptor blockade. In 30 anesthetized dogs, trains of five electrical stimuli (1 mA; 1 ms) were delivered immediately after the P wave of the ECG to mediastinal nerves associated with the superior vena cava. Regional atrial electrical events were monitored with 191 atrial unipolar electrodes. Mediastinal nerve sites were identified that reproducibly initiated atrial arrhythmias. These sites were then restimulated following 1 h (time control, n = 6), or the intravenous administration of naftopidil (alpha(1)-adrenergic blocker: 0.2 mg/kg, n = 6), yohimbine (alpha(2)-adrenergic blocker: 1 mg/kg, n = 6) or both (n = 8). A ganglionic blocker (hexamethonium: 1 mg/kg) was tested in four dogs. Stimulation of mediastinal nerves sites consistently elicited atrial tachyarrhythmias. Repeat stimulation after 1 h in the time-control group exerted a 19% decrease of the sites still able to induce atrial tachyarrhythmias. Hexamethonium inactivated 78% of the previously active sites. Combined alpha-adrenoceptor blockade inactivated 72% of the previously active sites. Bradycardia responses induced by mediastinal nerve stimulation were ...Continue Reading

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Citations

Aug 26, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allison E GirasoleJean C Hardwick
Nov 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David D GibbonsJeffrey L Ardell
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeffrey L ArdellJ Andrew Armour
Apr 29, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Efrat Kurtzwald-JosefsonMichael Arad
Oct 11, 2014·Autonomic Neuroscience : Basic & Clinical·Jeffrey L ArdellJ Andrew Armour
Dec 17, 2014·Future Cardiology·Dominik LinzUlrich Schotten
Apr 26, 2014·Circulation Research·Peng-Sheng ChenStanley Nattel
Nov 22, 2018·Frontiers in Physiology·Ghassen ChenitiFrederic Sacher
Nov 18, 2015·The Journal of Physiology·Pradeep S RajendranKalyanam Shivkumar
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Siamak SalavatianJeffrey L Ardell
Sep 29, 2019·European Journal of Clinical Investigation·Ahsan A KhanAlena Shantsila
Dec 13, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Alan SugruePaul A Friedman
Apr 26, 2017·Molecular Medicine Reports·Ying-Ying ChenLiang-Rong Zheng
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Oct 1, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Valerie Y H van WeperenOlujimi A Ajijola

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