PMID: 8942402Nov 1, 1996Paper

alpha-Adrenoceptor mechanisms of thermoregulation during cold challenge in humans

Clinical Science
S M FrankP K Wu

Abstract

1. Previous studies on the thermoregulatory effects of alpha-adrenoceptor antagonists have been performed primarily in animals and the findings have been inconsistent. There is evidence for thermoregulatory impairment by alpha-adrenergic antagonists in humans not exposed to cold, but the effects of alpha-adrenergic blockade during cold challenge have not been investigated. 2. Fourteen healthy human volunteers (seven elderly, aged 55-68 years and seven young, aged 19-27 years) were studied on three separate days and received three randomly assigned treatments; (i) control (no drug), (ii) low-dose phentolamine and (iii) high-dose phentolamine. On each day cold intravenous saline (4 degrees C) was given until both vasoconstriction and shivering were triggered or a maximum fluid volume (40 ml/kg) was delivered. Core temperature, peripheral vasoconstriction and metabolic heat production were measured. 3. The alpha-adrenoceptor antagonist caused a dose-dependent inhibition of vasoconstriction in the elderly but did not impair vasoconstriction in the young subjects at the doses that were given. Shivering and metabolic heat production were unaffected by alpha-adrenergic blockade in the elderly or in the young. 4. These findings illustr...Continue Reading

Citations

Aug 17, 2001·Anesthesiology·D I Sessler
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S M FrankD S Goldstein
Feb 22, 2001·Journal of Applied Physiology·J W CastellaniM N Sawka
Dec 10, 2002·Medicine and Science in Sports and Exercise·John W CastellaniShawn G Rhind
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Anthony G DoufasDaniel I Sessler
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Sep 25, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·E SøndergaardN Jessen
Aug 23, 2003·Anesthesia and Analgesia·Katsumi OkuyamaTeruo Kumazawa
Oct 10, 2018·Anesthesia and Analgesia·Yehoshua N SchachamDaniel I Sessler
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Jan 1, 2013·Global Cardiology Science & Practice·Hesham Saad, Mostafa Aladawy
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Dec 10, 2003·Best Practice & Research. Clinical Anaesthesiology·Anthony G Doufas

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