alpha-Adrenoceptor subtypes mediating regional kidney blood flow responses to renal nerve stimulation

Autonomic Neuroscience : Basic & Clinical
Gabriela A EppelRoger G Evans

Abstract

The mechanisms underlying the relative insensitivity of the renal medullary circulation to renal sympathetic nerve stimulation (RNS) remain unknown. Therefore, we tested the effects of systemic alpha(1)- and alpha(2)-adrenoceptor blockade on responses to electrical RNS in pentobarbitone anaesthetized rabbits. Renal blood flow (RBF), cortical laser Doppler flux (CLDF), and to a lesser extent medullary LDF (MLDF) were reduced by RNS in a frequency-dependent manner. Prazosin decreased responses of RBF and CLDF, but not MLDF, to RNS. For example, during the control period 4 Hz stimulation reduced RBF, CLDF and MLDF by 85+/-3%, 89+/-2%, and 20+/-12%, respectively, but after prazosin, corresponding responses were 39+/-3%, 42+/-5% and 28+/-7%, respectively. Prazosin markedly blunted pressor and renal vasoconstrictor responses to intravenous phenylephrine, without altering pressor responses to intravenous xylazine. Rauwolscine enhanced renal vasoconstrictor responses to RNS, although this was statistically significant for RBF and CLDF but not MLDF. For example, during the control period 2 Hz stimulation reduced RBF, CLDF and MLDF by 63+/-7%, 58+/-7%, and 29+/-17%, respectively, and after rauwolscine, corresponding responses were 83+/-4...Continue Reading

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Citations

May 1, 2009·American Journal of Physiology. Renal Physiology·Tiffany L Thai, William J Arendshorst
Aug 4, 2004·Pflügers Archiv : European journal of physiology·Niwanthi W RajapakseRoger G Evans
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·Roger G EvansNiwanthi W Rajapakse
May 14, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Niwanthi W RajapakseRoger G Evans
Jul 20, 2007·American Journal of Physiology. Renal Physiology·Tilmann DittingRoland Veelken
Oct 12, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael HultströmA Erik G Persson
Feb 26, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristina RodionovaTilmann Ditting
Oct 1, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gabriela A EppelRoger G Evans

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