alpha-Amanitin: inactivation by bovine lactoperoxidase

Experientia
P W MorrisW G Logas

Abstract

The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.

References

Jun 1, 1977·Die Naturwissenschaften·T Wieland
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J WehlandK Weber
Jan 1, 1976·Annual Review of Biochemistry·M Morrison, G R Schonbaum
Jan 1, 1975·Annual Review of Biochemistry·P Chambon
Dec 1, 1975·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·L G Hanelin, A A Moss
Apr 15, 1976·FEBS Letters·H Faulstich, M Cochet-Meilhac
Jun 15, 1973·Deutsche medizinische Wochenschrift·U Fauser
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A M LengsfeldW Hasselbach
May 2, 1974·European Journal of Biochemistry·W BurgermeisterR Winkler

Citations

Mar 10, 2000·Toxicon : Official Journal of the International Society on Toxinology·A ZhelevaZ Zhelev
Jun 3, 2018·The Journal of Microbiology·Demba SarrBalázs Rada

Related Concepts

Amanitins
Metazoa
Bos indicus
Drosophila melanogaster
Lactoperoxidase
Ovoperoxidase
RNA Polymerase II
In Vitro [Publication Type]

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.