alpha-Amanitin: inactivation by bovine lactoperoxidase

P W MorrisW G Logas


The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.


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Mar 10, 2000·Toxicon : Official Journal of the International Society on Toxinology·A ZhelevaZ Zhelev
Jun 3, 2018·The Journal of Microbiology·Demba SarrBalázs Rada

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