PMID: 7539052Jun 1, 1995Paper

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors mediate excitotoxicity in the oligodendroglial lineage

Journal of Neurochemistry
A YoshiokaD Pleasure

Abstract

We demonstrate by reverse transcriptase-polymerase chain reaction and Southern blotting that an immortalized rat oligodendroglial cell line (CG-4) expresses the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor (GluR) genes GluR2-7, KA-1, and KA-2 and that nonimmortalized cells of the rat oligodendroglial lineage express the GluR1-3, GluR5-7, KA-1, and KA-2 genes. Lactic dehydrogenase release assays show that both immortalized and nonimmortalized cells of the oligodendroglial lineage are damaged by a 24-h exposure to 500 microM kainate or 5 mM L-glutamate, but not by a 24-h exposure to up to 10 mM alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA). Damage is prevented by the non-NMDA GluR channel inhibitor 6-cyano-7-nitroquinoxaline-2,3-dione and is also averted if Ca2+ is removed from the culture medium. Cyclothiazide, which blocks desensitization of AMPA-preferring GluRs, increases cytotoxicity of kainate as well as inducing toxicity of AMPA. We conclude that cells of the oligodendroglial lineage express a population of AMPA-preferring and possibly also kainate-preferring GluR channels that are capable of mediating Ca(2+)-dependent excitotoxicity and that AMPA-induced cytotoxicity is blocked by desensitization o...Continue Reading

Citations

May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R L Stariha, S U Kim
Jul 11, 2003·Annals of the New York Academy of Sciences·Anthony J GroomLechoslaw Turski
May 6, 2003·Annals of Neurology·Jennifer L TakahashiV Wee Yong
Oct 6, 2005·Glia·Carlos MatuteMaría-Victoria Sánchez-Gómez
Jun 30, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Stephen A Back
Apr 2, 2014·Glia·Stephen A Back, Paul A Rosenberg
Feb 14, 2016·Muscle & Nerve·Pia Crone ChristensenPeter K Stys
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eileen McCrackenJames McCulloch
Sep 28, 2005·Neurochemical Research·Brandon A MillerMichael S Beattie
Mar 1, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Charanjit KaurEng-Ang Ling
Jul 23, 2013·PLoS Biology·Carsten FrühbeisEva-Maria Krämer-Albers
Dec 17, 2015·Translational Stroke Research·Qasim AlhadidiZahoor A Shah
Dec 24, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M BardoulN König
Jun 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E A IrvingD Dewar
May 17, 2007·Journal of Anatomy·Carlos MatuteFernando Pérez-Cerdá
Dec 28, 2006·Neurochemical Research·Joyce A Benjamins, Liljana Nedelkoska
Sep 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean E Merrill
Jun 6, 2003·Journal of Neurochemistry·Takayuki ItohDavid Pleasure
Apr 9, 2015·Frontiers in Cellular Neuroscience·Aristeidis A KritisTheofanis D Vavilis
Feb 14, 2012·Glia·Israel Sekler, William F Silverman
Oct 3, 2018·Frontiers in Molecular Neuroscience·Manuel Canedo-AnteloMaría Victoria Sánchez-Gómez
Jan 13, 2000·Neuropathology and Applied Neurobiology·J E Merrill, N J Scolding
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Deborah DewarMark P Goldberg
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Frances E Jensen
Jan 6, 2012·Neuron Glia Biology·R Douglas Fields
Nov 1, 2016·Journal of Neurochemistry·Steven W Barger
Dec 11, 2013·Translational Stroke Research·Mingke Song, Shan Ping Yu
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wenbin DengFrances E Jensen
Dec 28, 2002·Journal of Neuroscience Research·Paul A RosenbergJoseph J Volpe
Apr 12, 2006·Journal of Neurochemistry·Wenbin DengFrances E Jensen

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