Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors signaling complexes in Bergmann glia

Journal of Neuroscience Research
A MillánArturo Ortega

Abstract

Glutamate, the major excitatory neurotransmitter, induces a wide array of signals from the membrane to the nucleus regulating gene expression. In Bergmann glia, Ca2+ -permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole- propionic acid (AMPA) receptors are involved in the short- and long-term interactions between these cells and the neurons that they surround. After activation, AMPA receptors become tyrosine phosphorylated and by these means form multiprotein signaling complexes. To characterize these events, cultured chick Bergmann glia cells as well as chick cerebellar slices were exposed to glutamate, and, by using a combination of immunoprecipitation assays coupled to Western blot analysis, we identified several signaling proteins that become associated with these receptors. A dose- and time-dependent association among AMPA receptors, the focal adhesion kinase pp125FAK, the phosphatidylinositol-3 kinase and paxillin was found. These results extend the concept of the transducisome to AMPA receptors and provide a framework in which a plausible control of the cytoskeletal network by glutamate is taking place, most possibly through AMPA receptors.

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Citations

Jul 5, 2006·The Cerebellum·Tomas C Bellamy
Nov 28, 2013·Cellular and Molecular Life Sciences : CMLS·Stephanie M Robert, Harald Sontheimer
Sep 8, 2010·Neurochemistry International·Iliana BarreraArturo Ortega
Aug 23, 2011·Neurochemistry International·Zila Martínez-LozadaArturo Ortega
Nov 15, 2006·Neuropharmacology·Oliver P VossJames McCulloch
Dec 28, 2018·Journal of Neurochemistry·Rebeca Rosas-HernándezJ Alfredo Mendez
Jun 2, 2005·Journal of Neuroscience Research·J Alfredo MéndezArturo Ortega
Feb 14, 2008·Neurochemical Research·Rossana C ZepedaArturo Ortega

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