Abstract
Glutamate, the major excitatory neurotransmitter, induces a wide array of signals from the membrane to the nucleus regulating gene expression. In Bergmann glia, Ca2+ -permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole- propionic acid (AMPA) receptors are involved in the short- and long-term interactions between these cells and the neurons that they surround. After activation, AMPA receptors become tyrosine phosphorylated and by these means form multiprotein signaling complexes. To characterize these events, cultured chick Bergmann glia cells as well as chick cerebellar slices were exposed to glutamate, and, by using a combination of immunoprecipitation assays coupled to Western blot analysis, we identified several signaling proteins that become associated with these receptors. A dose- and time-dependent association among AMPA receptors, the focal adhesion kinase pp125FAK, the phosphatidylinositol-3 kinase and paxillin was found. These results extend the concept of the transducisome to AMPA receptors and provide a framework in which a plausible control of the cytoskeletal network by glutamate is taking place, most possibly through AMPA receptors.
References
Aug 7, 1992·Cell·I D HilesN F Totty
Jan 1, 1990·Glia·A H Cornell-BellS J Smith
Jan 1, 1991·Neuroscience·A OrtegaV I Teichberg
Jan 1, 1990·Neuroscience·P SomogyiJ D Roberts
Jan 12, 1994·Neuroreport·T LópezA Ortega
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Jan 12, 1996·The Journal of Biological Chemistry·J H HankeP A Connelly
Jul 15, 1997·The Journal of Physiology·B A Clark, B Barbour
Nov 14, 1997·The Journal of Biological Chemistry·J L JoyalD B Sacks
Aug 1, 1998·Brain Research. Molecular Brain Research·T LópezA Ortega
Sep 5, 1998·Neuron·I SongR L Huganir
Jan 19, 1999·Nature·T HayashiT Yamamoto
Dec 2, 1999·Experimental Cell Research·B Vanhaesebroeck, M D Waterfield
Jun 9, 2000·Annual Review of Physiology·M Sheng, D T Pak
Jun 22, 2000·Nature Neuroscience·H HusiS G Grant
Jun 29, 2000·Trends in Pharmacological Sciences·V Gallo, C A Ghiani
Nov 9, 2000·Neuroscience·Y KoyamaA Baba
Mar 30, 2001·Neuroreport·S IshiuchiS Ozawa
May 8, 2001·Science·M IinoS Ozawa
Oct 26, 2001·Journal of Neurochemistry·Y RongM Baudry
Dec 18, 2001·Journal of Neuroscience Research·A MillánA Ortega
Jan 10, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Tracee S Panetti
Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Peter Storz, Alex Toker
Mar 21, 2002·Journal of Neurochemistry·Michael S PerkintonRobert J Williams
Sep 26, 2002·The Journal of Biological Chemistry·Natalie LavineHubert H M Van Tol
Dec 10, 2002·The Journal of Biological Chemistry·Susana Santos CorreiaAna Luísa Carvalho
May 27, 2003·Neuron·Heng-Ye ManYu Tian Wang
Feb 21, 2004·The EMBO Journal·Gholamreza AhmadianYu Tian Wang
Mar 16, 2004·The European Journal of Neuroscience·Limin MaoJohn Q Wang
Citations
Jul 5, 2006·The Cerebellum·Tomas C Bellamy
May 26, 2005·Pharmacological Reviews·Claire L PalmerJeremy M Henley
Nov 20, 2013·Neurochemical Research·Daniel MartínezArturo Ortega
Nov 28, 2013·Cellular and Molecular Life Sciences : CMLS·Stephanie M Robert, Harald Sontheimer
Mar 5, 2015·Neurochemical Research·Marco Flores-MéndezArturo Ortega
Sep 8, 2010·Neurochemistry International·Iliana BarreraArturo Ortega
Aug 23, 2011·Neurochemistry International·Zila Martínez-LozadaArturo Ortega
Nov 15, 2006·Neuropharmacology·Oliver P VossJames McCulloch
Jun 13, 2006·Neuroscience·M E González-MejiaA Ortega
Dec 28, 2018·Journal of Neurochemistry·Rebeca Rosas-HernándezJ Alfredo Mendez
Jun 2, 2005·Journal of Neuroscience Research·J Alfredo MéndezArturo Ortega
May 31, 2006·Neurochemical Research·Moisés MoralesArturo Ortega
Feb 14, 2008·Neurochemical Research·Rossana C ZepedaArturo Ortega