PMID: 7515267Feb 1, 1994Paper

Alpha and beta thalassaemia among Chinese children in Guangxi Province, P.R. China: molecular and haematological characterization

British Journal of Haematology
R LiangT H Huisman

Abstract

We have studied nearly 100 patients with beta-thalassaemia major and 60 patients with Hb H disease who were attending the Haematology Clinic of Guangxi Medical College. Treatment of the patients was limited and only a few patients with beta-thalassaemia major received blood transfusion(s). As a result, the severe anaemia has led to early death at 3-4 years for beta zero-thalassaemia homozygotes, and 8-12 years for beta(+)-thalassaemia homozygotes. Four beta-thalassaemia alleles are responsible for nearly 90% of all beta-thalassaemia chromosomes. This information has resulted in the initiation of a prenatal testing programme at the local level. The patients with Hb H disease maintained a haemoglobin level of 6-10 g/dl and early death was infrequently observed. The --SEA deletion was the major type of alpha-thalassemia-1, while three smaller deletions (-2.7, -3.7 and -4.2 kb) and two nondeletional alpha-thalassaemia determinants (Hbs Constant Spring and Quong Sze) were the alpha-thalassaemia-2 types.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Dec 1, 1977·The Journal of Clinical Endocrinology and Metabolism·D C DeVivoA S Pagliara
May 1, 1992·British Journal of Haematology·D K BowdenD R Higgs
Jan 1, 1992·Hemoglobin·X J WenW X Lin
Jun 1, 1990·Human Genetics·A KutlarT H Huisman
Nov 1, 1991·American Journal of Hematology·J B ZhaoT H Huisman
Jul 1, 1986·Human Genetics·A E FeliceT H Huisman
Jun 1, 1987·British Journal of Haematology·Y C GuT H Huisman
Feb 1, 1968·British Journal of Haematology·J A McBrideR Shapley
Oct 1, 1993·Hemoglobin·W SiriboonJ Svasti
Dec 12, 1959·Nature·K BETKEI SCHLICHT

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Citations

Jul 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chunming DingY M Dennis Lo
Oct 1, 1994·British Journal of Haematology·T P MolchanovaT H Huisman
Jun 6, 2009·Clinical Biochemistry·Shirley HendersonJohn Old
Jun 29, 2000·Baillière's Clinical Haematology·J FlintJ B Clegg
Nov 14, 2000·American Journal of Hematology·V Oron-KarniD Rund
Sep 8, 1998·Hemoglobin·S N Khan, S Riazuddin
Jun 6, 1998·Pediatric Hematology and Oncology·A C LeeK T So

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