Alpha, beta, and gamma mineralocorticoid receptor messenger ribonucleic acid splice variants: differential expression and rapid regulation in the developing hippocampus

Endocrinology
D M VázquezH Akil

Abstract

Two different types of corticoid receptor molecules bind circulating corticosterone in brain: mineralocorticoid receptors (MR) and glucocorticoid receptors. MR exhibit the highest affinity for the endogenous glucocorticoid in the rat, corticosterone. During development, low corticosterone levels influence neurogenesis, and these effects are probably MR mediated. Three MR complementary DNA clones, alpha, beta, and gamma, have been identified in the rodent. All of these MR complementary DNA clones have identical coding regions, but differ significantly at the 5'-untranslated end. Although the functional significance of these three messenger RNA (mRNA) species remains unknown, one hypothesis is that they reflect the ability of the brain to regulate the expression of MR, allowing multiple factors to differentially control transcription in a tissue- and time-specific manner. To investigate this possibility, we examined the presence of these distinct mRNA forms in the developing rat hippocampus (HC). In situ hybridization with specific alpha, beta, and gamma complementary RNA probes was performed in the HC of 3-, 5-, 7-, 12-, 14-, 28-, 35-, and 65-day-old animals. We found that there is differential expression of these forms in each ...Continue Reading

References

Jan 1, 1978·Psychoneuroendocrinology·A Ardeleanu, N Sterescu
Jan 1, 1976·Developmental Psychobiology·E Howard
Apr 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·W D Knowles
Jul 16, 1991·Brain Research. Developmental Brain Research·J A van EekelenE R de Kloet
Oct 1, 1985·Physiological Reviews·J S Meyer
Oct 1, 1989·Experimental Neurology·P W Landfield, J C Eldridge
Apr 1, 1989·Experimental Neurology·H HashimotoM C Bohn
Jan 1, 1988·Progress in Brain Research·E R De KloetS Levine
Nov 1, 1988·Pediatric Research·L L LeeperS J Henning
Jan 1, 1980·Anatomy and Embryology·R Loy
Jun 1, 1995·Journal of Molecular Endocrinology·M CastrénF Holsboer
Sep 8, 1995·The Journal of Biological Chemistry·M C ZennaroP J Fuller
Nov 30, 1994·Annals of the New York Academy of Sciences·M JoëlsW J Wadman
Aug 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·S J ListwakH J Whitfield

❮ Previous
Next ❯

Citations

Mar 4, 2005·Hippocampus·Kristen L BrunsonRoland A Bender
Jul 4, 2016·Trends in Molecular Medicine·Vivien Chevaleyre, Rebecca A Piskorowski
Aug 1, 2018·International Journal of Molecular Sciences·Kalina Duszka, Walter Wahli
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T BrabhamD M Vázquez
Apr 23, 2005·The European Journal of Neuroscience·Christopher R PryceAna Jongen-Rélo
Nov 21, 2019·Molecular Psychiatry·Katharine E McCannSerena M Dudek
Dec 24, 2021·Journal of Neuroendocrinology·Eva M G VihoOnno C Meijer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.