alpha-blocker monotherapy in the treatment of nocturia in men with lower urinary tract symptoms: a prospective study of response prediction

BJU International
Jae-Seung PaickSoo Woong Kim

Abstract

To determine the efficacy of an alpha-adrenoceptor antagonist, terazosin, in reducing nocturia in men with lower urinary tract symptoms (LUTS), and to identify the factors predicting treatment outcome. In all, 100 patients were treated with 2 mg of terazosin once daily for the first 7 days, and continued to receive 4 mg of terazosin once daily for the following 3 weeks. The men were assessed at baseline and at the end of treatment using uroflowmetry, the International Prostate Symptom Score (IPSS), and the degree of nocturia estimated from a frequency-volume chart (FVC) and objectively. On the FVC, 27 patients reported that the terazosin treatment reduced their nocturia by more than half, and 14 reported a reduction of 25-49%. On the IPSS, 31 patients reported that the treatment reduced their nocturia by more than half and 27 reported a reduction of 25-49%. On multivariate regression analysis, only the actual number of nightly voids on the FVC was associated with a 2.1-fold chance of an improvement of >25% in objective nocturia (P = 0.016). Using a comparable model, a greater nocturia score on the IPSS was associated with a higher likelihood of improvement in subjective nocturia (odds ratio, 1.653; 95% confidence interval, 1.07...Continue Reading

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Citations

Apr 20, 2011·Prostate Cancer and Prostatic Diseases·J Y KangH-L Lee
Oct 1, 2009·Therapeutic Advances in Urology·Roger R Dmochowski, Alex Gomelsky
May 19, 2007·Biomedical Research·Kimio SugayaYoshihide Ogawa
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Mar 2, 2011·BJU International·Dev Mohan GulurMarcus J Drake
Dec 5, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu IshizukaKarl-Erik Andersson
Feb 22, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Vasileios SimaioforidisCharalambos Deliveliotis
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Apr 22, 2016·American Journal of Physiology. Renal Physiology·Zachary C Danziger, Warren M Grill
Jul 31, 2007·Neurourology and Urodynamics·Kimio SugayaYoshihide Ogawa
Apr 1, 2010·BJU International·Marleen M Van DijkMartin C Michel
Feb 20, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Tim SchneiderMartin C Michel
Feb 29, 2020·Ci Ji Yi Xue Za Zhi = Tzu-chi Medical Journal·Cheng-Ling LeeHann-Chorng Kuo

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