Alpha-blockers impact stent-related symptoms: a randomized, double-blind, placebo-controlled trial

Journal of Endourology
Syed M Nazim, M Hammad Ather

Abstract

Ureteral stents are indispensable tools in endourology, although they often are associated with bothersome lower urinary tract symptoms. This study was conducted to evaluate the effect of alfuzosin on urinary symptoms, quality of life, and pain in patients after Double-J ureteral stent placement in a randomized, placebo-controlled trial. This study was conducted from July 2008 to May 2009. A total of 130 patients underwent placement of a Double-J stent after retrograde semirigid ureteroscopy for ureteral stones. They were randomized in two groups. Group 1 (n=65) received alfuzosin 10 mg once daily and group 2 (n=65) received placebo for 1 week. Both groups also received standardized analgesia. The stent symptoms were measured and recorded 1 week after the procedure. Statistical analyses were performed using the chi-square test and Student t test with P<0.05 considered significant. The demographic profile including patient and stone-related parameters were comparable. Group 1 had significantly less urinary symptoms (P<0.05). The quality-of-life assessment was better in the alfuzosin arm than in the placebo arm (P<0.001). The mean pain score was 1.15 in group 1 and 3.89 in the placebo group (P<0.001). None of the patients in eith...Continue Reading

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Citations

Nov 26, 2015·Expert Opinion on Drug Safety·Nadya E YorkJames E Lingeman
Nov 5, 2013·The Urologic Clinics of North America·Shubha DeBodo Knudsen
Jul 31, 2014·World Journal of Urology·Richard H ShinGlenn M Preminger
Feb 23, 2020·Arab Journal of Urology·Konstantinos DeliveliotisAthanasios E Dellis
Feb 20, 2016·Experimental and Therapeutic Medicine·Peng ZhangGang Wang
Jun 14, 2019·Proceedings·Preston A MilburnMarawan M El Tayeb

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Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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