Sep 11, 1989

alpha-Bungarotoxin interacts with the rat brain tachykinin receptors

FEBS Letters
Utkin YuNV I Tsetlin

Abstract

alpha-Bungarotoxin (alpha Bgt) was shown to inhibit the binding of the 125I-labeled substance P (SP) and eledoisin (EL) to the rat brain membranes with Kl values of 8.0 +/- 5.0 x 10(-8) and 1.1 +/- 0.5 x 10(-6) M, respectively. Lower inhibitory activity was manifested by several other postsynaptically acting snake venom neurotoxins. The alpha Bgt inhibition of SP binding with a Kl value of 8.5 +/- 5.5 x 10(-8) M to solubilized preparations of the rat brain membranes was demonstrated. The capacity to displace SP was found for d-tubocurarine and phencyclidine, although at concentrations considerably higher than those affecting the nicotinic acetylcholine receptors (AChRs). The results obtained suggest that some of the alpha Bgt-binding polypeptides, distinct from neuronal AChRs, may be functionally associated with the tachykinin receptors (TchR).

Mentioned in this Paper

Snake Venoms
Tissue Membrane
Brain
Tachykinin Receptor
Synaptic Receptors
Neuronal
Phencyclidine
Metabolic Inhibition
Hypothalamic Substance P
Tac1

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