PMID: 9650080Jul 3, 1998Paper

alpha-Crystallin polymers and polymerization: the view from down under

International Journal of Biological Macromolecules
R C Augusteyn

Abstract

Several models have been proposed for the quaternary structure of alpha-crystallin. Some suggest the subunits are arranged in concentric shells. Others propose that the subunits are in a micelle-like arrangement. However, none is able to satisfactorily account for all observations on the protein and the quaternary structure of alpha-crystallin remains to be established. In this review, factors contributing to the assembly and polymerization are examined in order to evaluate the different models. Consideration of the variations in particle size and molecular weight under different conditions leads to the conclusion that alpha-crystallin cannot be a micelle or a layered structure. Instead, it is suggested that the protein may be assembled from a 'monomeric' unit comprising eight subunits arranged in two tetramers with cyclic symmetry. The octameric unit is proposed to be disc-like particle with a diameter of 9.5 nm and a height of 3 nm. The larger particles, chains and sheet-like structures commonly observed are assembled from the octamers. Structural predictions indicate that the polypeptide may be folded into three independent domains which have different roles in the structural organization and functions of the protein. It is ...Continue Reading

References

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Citations

Apr 16, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Barry L Cole
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Stefan JehleRachel E Klevit
Dec 4, 2004·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Robert C Augusteyn
May 30, 2002·Biological & Pharmaceutical Bulletin·Akira Kamei, Nobuyuki Matsuura
Mar 30, 2011·Proteins·Tue RasmussenMarina R Kasimova
Oct 3, 2007·Molecular and Cellular Biochemistry·Latha S KallurEdathara C Abraham
Apr 4, 2006·Biochimica Et Biophysica Acta·Tooru NakamuraNoriko Fujii
Apr 12, 2000·Biochemistry·J VanhoudtJ Clauwaert
Apr 8, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yutaka SadakaneKazuya Nakagomi

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