PMID: 9650075Jul 3, 1998Paper

alpha-Crystallin quaternary structure and interactive properties control eye lens transparency

International Journal of Biological Macromolecules
A Tardieu

Abstract

The eye lens is the foremost biological system where function is directly under control of the physico-chemical properties of the cytoplasmic macromolecular solution. Indeed, lens transparency and opacity, lens refractive index gradient and viscosity, are the result of the structural and interactive properties of the crystallins, of their stability, of the fine tuning of their interaction potentials and associations at different levels of organization. Among the different crystallin classes, alpha-crystallins have represented a major challenge for a long time. The alpha-crystallin secondary, tertiary and quaternary structures are still unknown. On the functional side, however, it is established that alpha-crystallin quaternary structure and repulsive interactions determine lens transparency, whereas the alpha-crystallin chaperone effect most probably plays a role in the aging process. In the present paper, we recall the physico-chemical properties and the quaternary structure features of alpha-crystallins that were demonstrated to control light scattering and transparency. The interest of a crystallin mixture for lens function is discussed. Then, a formal approach is proposed to design models for the alpha-crystallin quaternary...Continue Reading

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Citations

Apr 30, 2003·Journal of Structural Biology·Juan Manuel García-Ruiz
Sep 1, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Mohammed A AldahmeshFowzan S Alkuraya
Jun 10, 2000·European Journal of Biochemistry·J VanhoudtJ Clauwaert
Jan 11, 2002·Molecular and Cellular Biology·David W NeesJoram Piatigorsky
Oct 30, 2014·Cellular and Molecular Life Sciences : CMLS·Teresa M TreweekJohn A Carver
Jun 28, 2015·Biochimica Et Biophysica Acta·Martin HaslbeckSevil Weinkauf
Jan 3, 2001·Medical Hypotheses·L Saso, B Silvestrini
Feb 16, 2006·Biochimica Et Biophysica Acta·Fériel Skouri-PanetStéphanie Finet
Aug 5, 2018·The Journal of Biological Chemistry·Zhenying LiuCong Liu
Aug 15, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sujuan JiaJoram Piatigorsky
Feb 26, 2019·The Journal of Biological Chemistry·Yana A LyonRyan R Julian
Jul 17, 2020·Frontiers in Bioengineering and Biotechnology·Ingrid GarzónMiguel Alaminos
Aug 6, 2020·International Journal of Molecular Sciences·Mareike RiedlMartin Haslbeck
Dec 6, 2020·International Journal of Biological Macromolecules·Ajamaluddin MalikMohammad Z Ahmed
Jan 13, 2021·Nature Structural & Molecular Biology·Philipp W N SchmidJohannes Buchner
Feb 1, 2008·Physical Review Letters·A StradnerP Schurtenberger
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Oct 31, 2014·The Journal of Physical Chemistry. B·Valentina VillariNorberto Micali
Oct 5, 2014·Experimental Eye Research·Andre A M Torricelli, Steven E Wilson

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