PMID: 6170978Aug 1, 1981Paper

alpha-Fetoprotein and albumin genes are in tandem in the mouse genome

Proceedings of the National Academy of Sciences of the United States of America
R S IngramS M Tilghman

Abstract

The urine alpha-fetoprotein (AFP) and serum albumin genes most probably arose in evolution as the consequence of a duplication of a common ancestral gene. They have both been previously mapped to chromosome 5 in the mouse. We now have evidence that these genes are closely linked. By using a unique copy DNA probe derived from previously cloned AFP 5' flanking DNA, a recombinant DNA phage has been isolated, from a bacteriophage DNA library, that contains sequences flanking the 5' end of the AFP gene and the 3' end of the albumin gene. Restriction endonuclease mapping and DNA sequence determination of the recombinant phage and comparison to total genomic DNA confirmed that the genes are in tandem, 13.5 kilobase pairs apart, with the albumin gene to the 5' side of the AFP gene. Thus, they are transcribed from the same strand of DNA.

References

Apr 29, 1976·Nature·E Ruoslahti, W D Terry
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E Ruoslahti, E Engvall
Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·R P LiftonD S Hogness
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D SwanF H Ruddle
Jan 1, 1979·Annual Review of Biochemistry·L H Kedes
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S H HughesH E Varmus
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J GusellaD Housman
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D KioussisJ M Taylor
Aug 10, 1979·Science·S NagaseS Shumiya
Jun 11, 1979·Nucleic Acids Research·D TuanB G Forget
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·T ManiatisD G Kleid
Oct 15, 1973·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D GitlinJ D Gitlin
Aug 1, 1974·Differentiation; Research in Biological Diversity·J LindgrenE Ruoslahti
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M B Gorin, S M Tilghman
Jun 1, 1980·The Journal of Experimental Medicine·P D'EustachioF H Ruddle
Oct 1, 1980·Cell·A EfstratiadisN J Proudfoot
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T D SargentJ Bonner
Jan 10, 1980·Nature·M R LernerJ A Steitz

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Citations

Jan 1, 1989·Molecular & General Genetics : MGG·M JoseJ M Sala-Trepat
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C A Kozak, D A Stephenson
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C A Kozak, D A Stephenson
Nov 1, 1988·Somatic Cell and Molecular Genetics·R C MifflinJ Papaconstantinou
Feb 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·J H Kelly, G J Darlington
Feb 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·X J GuanS M Tilghman
Jan 1, 1983·Advances in Enzyme Regulation·L BelangerJ M Boucher
Sep 1, 1989·Journal of Reproductive Immunology·D C Hooper, R G Evans
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S M Tilghman, A Belayew
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V PachnisS M Tilghman
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K WiebauerM H Meisler
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A WeydertJ L Guénet
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L Muglia, L B Rothman-Denes
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·P E Gibbs, A Dugaiczyk
Sep 24, 1983·Nucleic Acids Research·W F MarzluffS S Wang
Sep 11, 1984·Nucleic Acids Research·L Muglia, J Locker
Jan 11, 1985·Nucleic Acids Research·L Kunnath, J Locker
May 1, 1986·Annals of Human Genetics·Y H EdwardsP H Butterworth
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·D K JinM H Feuerman
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Shirley M Tilghman
Mar 1, 1992·The American Journal of the Medical Sciences·D BallE Alpert
Feb 5, 1985·Journal of Molecular Biology·C H SellemD Cassio
Jul 15, 1982·Biochemical Pharmacology·D W Nebert, M Negishi
Jan 1, 1983·Annals of the New York Academy of Sciences·P P MinghettiA Dugaiczyk

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