Alpha-fetoprotein and albumin in experimentally-induced exencephaly in the rat

C J Smith, P C Kelleher


Alpha-fetoprotein and albumin were quantified in the sera and amniotic fluids from control, Vitamin A-treated non-exencephalic and Vitamin A-treated exencephalic rat fetuses. Exencephaly was associated with amniotic fluid alpha-fetoprotein concentrations which were significantly elevated over those of Vitamin A-treated non-exencephalic and of untreated fetuses. Amniotic fluid albumin concentrations also were higher in the exencephalic fetuses than in the non-exencephalic fetuses. Serum alpha-fetoprotein and albumin concentrations were lower in the exencephalic than in the non-exencephalic fetuses. The results are cosistent with simple diffusion across a defective barrier as the cause of elevated amniotic fluid alpha-fetoprotein concentrations in the presence of open neural tube defects. This experimental model of neural tube defects result in changes in amniotic fluid alpha-fetoprotein similar to those changes found in human amniotic fluid alpha-fetoprotein concentrations in the presence of neural tube defects.


Mar 1, 1976·Journal of the National Cancer Institute·S Sell, H Skelly
Jan 1, 1976·British Medical Bulletin·D J Brock
Aug 1, 1976·Analytical Biochemistry·J G Wieja, C J Smith
Dec 9, 1972·Lancet·T F Warner
Dec 9, 1972·Lancet·D J Brock, J B Scrimgeour
Nov 21, 1973·Nature: New Biology·J N MacriM I Evans
Dec 17, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·D J Brock
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jul 1, 1963·Journal of Neuropathology and Experimental Neurology·A S DEKABAN

Related Concepts

Abnormalities, Drug-Induced
Amniotic Fluid Index
Maternal-Fetal Exchange
Aquasol A

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