Alpha-fetoprotein and albumin uptake by mouse tissues during development.

Biology of the Neonate
J LabordaJ Uriel

Abstract

We have studied the evolution of the incorporation of alpha-fetoprotein (AFP) and albumin by mouse tissues from fetal to adult life. Mice were injected with 125I-labelled AFP or albumin and, 3 h later, blood and organs were removed and analyzed for their radioactive protein content. Results showed that all immature tissues examined took up both AFP and albumin from blood. AFP uptake was higher during fetal and early postnatal life and decreased with age. In general, the relative uptake of albumin was lower than that of AFP, and the time-course incorporation of both proteins was parallel in brain, liver and kidney. In other tissues such as white adipose tissue, brown adipose tissue and skin. AFP uptake decreased while albumin uptake remained almost constant or increased with age. In the fetal period, the strong AFP uptake in white adipose tissue contrasted with the much lower albumin incorporation by this tissue. Autoradiographs from sections of organs and entire animals confirmed the cytoplasmic localization of AFP and albumin. We conclude that AFP and albumin found in developing tissues, except for fetal liver and yolk sac, proceed mostly from blood uptake. These results agree with recent experimental data suggesting that the ...Continue Reading

Citations

Dec 2, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gerald J Mizejewski
Nov 26, 2002·Journal of Physiology, Paris·José M Medina, Arantxa Tabernero
Jun 1, 1994·The Journal of Clinical Investigation·G J AndersonW E Connor
Apr 8, 2015·International Journal of Cancer. Journal International Du Cancer·Chao ZhangGang Li
Nov 1, 1991·Journal of Neurochemistry·C VicarioJ M Medina
Mar 1, 1992·Journal of Cellular Physiology·J M TorresJ Uriel
Jan 2, 1991·International Journal of Cancer. Journal International Du Cancer·J M TorresJ Uriel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.