Alpha-fetoprotein-L3 and Golgi protein 73 may serve as candidate biomarkers for diagnosing alpha-fetoprotein-negative hepatocellular carcinoma

OncoTargets and Therapy
Zhiguo ZhangWan-Ju Xu

Abstract

Currently, there is no reliable biomarker for use in diagnosing alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC). Such a biomarker would aid in making an early diagnosis of AFP-negative HCC, ensuring the timely initiation of treatment. This study examined AFP-L3 and Golgi protein 73 (GP73) as candidate biomarkers for AFP-negative HCC. The affinity adsorption method and enzyme-linked immunoassays were separately used to determine serum levels of AFP-L3 and GP73 in 50 patients with AFP-negative HCC, 30 non-HCC patients, and 50 healthy subjects. Fifty percent of patients with AFP-negative HCC tested positive for AFP-L3, while 3.33% of non-HCC patients and 2.00% of healthy subjects were AFP-L3 positive. Patients with AFP-negative HCC had significantly higher serum levels of AFP-L3 compared to non-HCC patients and healthy individuals; however, there was no significant difference in the AFP-L3 levels of non-HCC patients and healthy subjects. Sixty-six percent of patients with AFP-negative HCC tested positive for GP73, while 10% of non-HCC patients and 0% of healthy subjects were GP73-positive. Patients with AFP-negative HCC had significantly higher serum levels of GP73 compared to non-HCC patients and healthy subjects,...Continue Reading

Citations

Apr 3, 2020·International Journal of Oncology·Yu-Xue GaoDe-Xi Chen
May 26, 2017·BioMed Research International·Bo LiYuanli Mao
May 29, 2018·Canadian Journal of Gastroenterology & Hepatology·Xiaoping Wang, Qiaoxia Wang
Sep 15, 2020·Frontiers in Oncology·Ting Wang, Kun-He Zhang

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Methods Mentioned

BETA
affinity

Clinical Trials Mentioned

NCT00000789

Software Mentioned

GraphPad Prism
GraphPad

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