alpha-Fluoromethylhistidine decreases the histamine content of the rat right atrium under the influence of sympathetic activity

Naunyn-Schmiedeberg's Archives of Pharmacology
I YoshitomiS Teramoto

Abstract

alpha-Fluoromethylhistidine (alpha-FMH; 65 mg/kg, i.p.), a specific inhibitor of histidine decarboxylase, significantly decreased the histamine content of the rat right atrium in a time-dependent manner; the maximal decrease of 22.2% was observed 4 h after injection. However, alpha-FMH had no significant effect on the histamine content of the left atrium or the ventricles. The alpha-FMH-induced decrease in the right atrial histamine content was not observed in rats pretreated with 6-hydroxydopamine (25 mg/kg, i.p.). Two i.p. injections of 10 and 5 mg/kg of propranolol and the cardioselective beta 1-adrenoceptor antagonist metoprolol almost completely inhibited the alpha-FMH-induced histamine decrease. On the other hand, phentolamine (10 mg/kg, i.p.) had no influence on the histamine-decreasing action of alpha-FMH. These results suggest that in the rat right atrium there is a histamine pool where a rapid turnover of histamine is maintained by normal sympathetic activity.

References

Jan 1, 1986·Circulation Research·A A Wolff, R Levi
Apr 1, 1986·Japanese Journal of Pharmacology·S KoyamaK Saeki
Nov 1, 1973·British Journal of Pharmacology·P F Mannaioni, F Moroni
Feb 1, 1972·Journal of Neurochemistry·K M Taylor, S H Snyder
Jul 1, 1971·European Journal of Pharmacology·H CorrodiW G Clark
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·K J BroadleyD A Owen

❮ Previous
Next ❯

Citations

Dec 12, 1994·European Journal of Pharmacology·J Van de VoordeB Vanheel
Jul 4, 2003·British Journal of Pharmacology·Julian CharlesChristine E Wright
Nov 6, 1998·Journal of Applied Physiology·X LiS N Mink

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.