PMID: 6409205Jun 25, 1983Paper

Alpha gliadin antibody levels: a serological test for coeliac disease

British Medical Journal
C O'FarrellyD G Weir

Abstract

The diagnostic value in coeliac disease of circulating antibodies to casein, crude gliadin, and alpha gliadin was assessed using an adaption of the enzyme linked immunosorbent assay system. alpha Gliadin was the only antigen which consistently separated 26 patients with untreated coeliac disease from 26 normal controls and 13 patients with chronic inflammatory bowel disease. The mean assay index for the 26 patients was 3.1 (SD 1.2) compared with 1.05 (0.5) for the normal controls and 1.1 (0.6) for patients with chronic inflammatory bowel disease. The alpha gliadin antibody levels of six patients with coeliac disease who had maintained a gluten free diet for at least two years were not significantly higher than normal (1.0 (0.4)). The validity of the test was determined in 90 consecutive patients who were being investigated for the presence of coeliac disease. Levels of alpha gliadin antibody were raised in 36 out of 44 patients found to have histologically proved coeliac disease and in six out of 46 subjects whose jejunal mucosa was normal. Serial alpha gliadin concentrations were measured in 12 patients with coeliac disease who had repeat jejunal biopsies performed six months after starting a gluten free diet. The levels of an...Continue Reading

References

Nov 18, 1972·Lancet·M J KendallC F Hawkins
Jul 1, 1983·Scandinavian Journal of Gastroenterology·C O'FarrellyD G Weir
Jan 1, 1981·Journal of Immunological Methods·M KiefferR R Coombs
Oct 8, 1964·The New England Journal of Medicine·R M KIVELD LIEBOWITZ

❮ Previous
Next ❯

Citations

Oct 1, 1989·Irish Journal of Medical Science·C Feighery
Aug 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·A ElewautM H De Baets
May 12, 1989·Journal of Immunological Methods·G PresaniM A Mangiarotti
Jul 11, 1987·Lancet·C P KellyD G Weir
Sep 16, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G Oberhuber
Mar 3, 1998·Journal of Pediatric Gastroenterology and Nutrition·T M Rossi, A Tjota
Sep 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Harvey, D B Jones
Jan 1, 1996·APMIS. Supplementum·S U Friis
May 1, 1987·Archives of Disease in Childhood·J KellyD G Weir
Jun 4, 1988·British Medical Journal·G K Holmes, P G Hill
Feb 22, 2012·Gut·Jonas F LudvigssonCarolina Ciacci
Oct 1, 1987·Journal of Clinical Pathology·C O'FarrellyD G Weir
Jun 1, 1995·Journal of Clinical Pathology·S R MerridewE J Williams
Nov 1, 1984·Postgraduate Medical Journal·M Shiner
Jun 1, 1995·Baillière's Clinical Gastroenterology·M Mäki
Dec 1, 1988·Tubercle·A J WilliamsD E Stableforth
Oct 1, 2014·Nutritional Neuroscience·Hanna Karakuła-JuchnowiczZofia Lasik
Jul 1, 1991·Clinics in Dermatology·L Galvez, Z M Falchuk
Apr 4, 2001·Alimentary Pharmacology & Therapeutics·S ZarM J Benson
Dec 7, 2010·The American Journal of Gastroenterology·Daniel A Leffler, Detlef Schuppan
Jul 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R M Barnes
Nov 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C O'FarrellyD G Weir
Oct 16, 1999·The American Journal of Gastroenterology·U SrinivasanC Feighery
Sep 1, 1996·The British Journal of Surgery·J V ReynoldsW A Tanner
May 23, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X L ZuoP V Desmond
Nov 20, 1998·Acta Paediatrica Japonica; Overseas Edition·B AltuntaşN Girgin
Nov 1, 1990·Journal of Gastroenterology and Hepatology·R C BartholomeuszD J Shearman
Dec 1, 1988·Gut·P A McCormickD P O'Donoghue
Jun 30, 2005·The American Journal of Gastroenterology·Sameer ZarDevinder Kumar
Feb 6, 2020·Expert Review of Gastroenterology & Hepatology·Hugo A PennyDavid S Sanders
Nov 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·C Rittmeyer, J M Rhoads
Jun 21, 2017·Journal of Gastroenterology·Anantdeep KaurMichael Wallach
Aug 31, 2002·Endocrine Reviews·Pekka CollinJorma Salmi
Jun 20, 2018·Biosensors·Tibor Pasinszki, Melinda Krebsz
Jul 23, 2020·Revista da Associação Médica Brasileira·Seval AkayHarun Akar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.