Alpha-glucosidase inhibitory activity of bromophenol purified from the red alga Polyopes lancifolia

Journal of Food Science
Keun Young KimSang Moo Kim

Abstract

A bromophenol, bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, was purified from the red alga Polyopes lancifolia. Its IC(50) values were 0.098 and 0.120 microM against Saccharomyces cerevisiae and Bacillus stearothermophilus alpha-glucosidases, respectively, and 1.00 and 1.20 mM against rat-intestinal sucrase and maltase. This bromophenol competitively inhibited S. cerevisiae alpha-glucosidase with a K(I) value of 0.068 microM and was very stable at pH 2 for 60 min at 37 degrees C. Therefore, this P. lancifolia bromophenol may have potential as natural nutraceutical for the management of type 2 diabetes.

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Citations

Nov 26, 2011·Journal of Biosciences·Dae-Sung LeeWon-Kyo Jung
Oct 25, 2013·Marine Drugs·Daisuke MikamiKoretaro Takahashi
Aug 9, 2011·Marine Drugs·Ming LiuXiukun Lin
Jan 1, 2013·Bioinformation·Sivasubramanian SuhithaDevadasan Velmurugan
Sep 10, 2014·Biotechnology Advances·Kannan R R RengasamyJohannes Van Staden
Aug 27, 2015·Marine Drugs·Yusrizam SharifuddinSiew-Moi Phang
Jul 23, 2013·Food Chemistry·Sinéad LordanR Paul Ross
Sep 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fanxin ZengDayong Peng
Jul 22, 2020·Journal of Food Biochemistry·Fernando Guerrero-RomeroClaudia I Gamboa-Gómez
Nov 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cai-Wei LiJih-Jung Chen

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