PMID: 2115016May 1, 1990Paper

Alpha heavy chain disease: a clinical study of 3 cases and review of the literature

Giornale di clinica medica
A M Comelli, B Paris

Abstract

Alpha-chain disease is a rare and interesting form of small intestinal immunoproliferative disease. In this paper we present three personal observations with different clinical manifestations. The first patients was admitted to the hospital because of weight loss, feet and ankles edema, and was complicated by intestinal occlusion that required an extensive enteric resection in urgency. After the operation, chemotherapy was carried out with good results at a five-years follow-up period. The second case, characterized by diffuse abdominal pain, diarrhea, weight loss and peripheral edema, was complicated by ileal perforation. An intestinal resection associated to mesenteric lymphnodes removal was performed. Chemotherapy and antibiotics were done successfully at a four-years follow-up period. In the last patient, admitted to our hospital because of abdominal discomfort, diarrhea and weight loss, a laparotomy was performed for confirming the diagnostic suspect and staging the disease. Only antibiotic therapy was done with good results at one-year follow-up period. We review and discuss the major clinical features and the main aspects of etiology, epidemiology, pathogenesis, pathology and therapy of this disease.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.