Alpha-helical CRF(9-41) prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats

Neuroreport
A KaskJ Harro

Abstract

We reported previously that the neuropeptide Y (NPY) Y1 receptor antagonist, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide (BIBP3226) has an anxiogenic-like effect in the elevated plus maze test in rats. In this study we investigated the effect of the corticotropin-releasing factor (CRF) receptor antagonist, alpha-helical-CRF(9-41) (alpha-h-CRF) on this response. BIBP3226 (5 microg, i.c.v.) induced an anxiogenic-like effect, which was blocked by pretreatment with alpha-h-CRF at a concentration (1 microg, i.c.v.) which alone failed to affect the elevated plus maze performance. Thus, the anxiogenic effect of a selective Y1 receptor blocker was prevented by the blockade of CRF receptors, suggesting antagonistic effects of endogenous NPY and CRF in shaping the response to novelty.

References

Aug 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·S L Handley, S Mithani
May 1, 1994·Neuroscience Research·E H LeeA Y Chen
Jan 1, 1995·Pharmacology & Therapeutics·S C Stanford

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Citations

Sep 6, 2002·Physiology & Behavior·Cheryl C MillerGaylen L Edwards
May 30, 2002·Neuroscience and Biobehavioral Reviews·Ants KaskRémi Quirion
Nov 5, 1998·Regulatory Peptides·A O SchaffhauserA Stricker-Krongrad
Jul 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·A KaskJ Harro
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
May 20, 2000·Neuropharmacology·I A AntonijevicA Steiger
Jun 24, 2004·Expert Opinion on Investigational Drugs·Eric P Zorrilla, George F Koob
Jan 6, 2009·Annals of the New York Academy of Sciences·Annika Thorsell
Jun 8, 2012·CNS Neuroscience & Therapeutics·Francesca GelfoFrancesco Angelucci
Sep 23, 2006·Frontiers in Neuroendocrinology·Carola EvaAlessandra Oberto
Feb 27, 2015·The International Journal of Neuropsychopharmacology·Gisela Patrícia BorgesEsther Berrocoso
Oct 1, 2010·Experimental Biology and Medicine·Ann M RasmussonDaniel E Forman

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