Abstract
The effect of varying concentrations of interferon-alpha (IFN-alpha) on the in vitro colony growth from all single-lineage human hematopoietic colony-forming progenitor cells was evaluated. IFN-alpha was tested at concentrations of 0, 2, 20, and 200 U/ml in optimally stimulated bone marrow cultures from each of 4 volunteer donors. Substantial donor-to-donor variability and distinct, lineage-specific patterns of stem cell sensitivity to IFN-alpha were observed. In the erythroid series, the more primitive progenitor or burst-forming unit (BFU-E) was substantially more resistant to growth inhibition at low IFN-alpha concentrations than the mature colony-forming unit (CFU-E). Colony growth by the megakaryocyte progenitor cell (CFU-Meg) was decreased by all concentrations of IFN-alpha which produced a biphasic, inhibitory dose response. The response of the colony-forming unit granulocyte/macrophage (CFU-GM) was heterogeneous among the donors tested. CFU-GM growth from 2 donors was insensitive to IFN-alpha at all concentrations. Conversely, CFU-GM from the other 2 donors manifested a steep dose-response curve that was similar to that of the CFU-E. These data demonstrate a heterogeneity of progenitor cell sensitivity to growth suppres...Continue Reading
References
Jun 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·P JamesonS E Grossberg
Jan 1, 1979·Journal of Biological Standardization
Aug 8, 1973·Nature: New Biology·T A McNeill, I Gresser
Jul 20, 1973·Nature·H KeshishyanE Jawetz
Aug 1, 1970·Journal of Cellular Physiology·B L Pike, W A Robinson
Feb 1, 1982·American Journal of Hematology·D S VermaK B McCredie
May 1, 1982·Annals of Internal Medicine·J U GuttermanZ Dziewanowski
Jan 1, 1980·Journal of Interferon Research·T R Winship, P I Marcus
Jan 1, 1984·Scandinavian Journal of Immunology·M H Claësson
Oct 15, 1982·Biochemical and Biophysical Research Communications·S GrantP B Fisher
Sep 1, 1981·The Journal of Clinical Investigation·E M MazurE Bruno
Citations
Nov 1, 1995·Critical Reviews in Oncology/hematology·G Zauli, L Catani
Sep 7, 2001·Cytokine & Growth Factor Reviews·K OritaniY Matsuzawa
Jun 10, 2000·British Journal of Haematology·C WickenhauserJ Thiele
Jun 5, 2008·Blood·Akiko YamaneYoshitaka Miyakawa
Dec 31, 2009·PloS One·Abigail A LamikanraDavid J Roberts
Mar 1, 1988·Blut·J S SchwambornP G Scheurlen
Apr 1, 1997·Journal of Gastroenterology·M SataK Tanikawa
Sep 1, 1996·Leukemia & Lymphoma·H Tilg, C Peschel
Sep 1, 1996·Leukemia & Lymphoma·C PeschelC Huber
Apr 20, 2010·Pharmaceuticals·Michael G Tovey, Christophe Lallemand
Jun 1, 1992·American Journal of Hematology·J C WangA Wong
Sep 4, 2004·Experimental Hematology·Shin-ichiro KawamotoYoshiaki Tomiyama
Jan 1, 1989·Annals of the New York Academy of Sciences·D OrlicC Sandoval
Dec 12, 2002·Hematology·Apostolia-Maria Tsimberidou, Francis J Giles
Mar 31, 2015·Annals of Hematology·Moshe TalpazRüdiger Hehlmann
Apr 21, 2016·Blood·Peter Geon KimGeorge Q Daley
Feb 12, 2008·Experimental and Molecular Pathology·V K SinghM H Whitnall
Jun 3, 2000·Nature Medicine·K OritaniY Matsuzawa
Jun 1, 2002·Leukemia·J Giron-MichelP Eid
May 6, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J ThieleR Fischer
Jun 24, 2004·Blood·Adrienne HalupaDwayne L Barber
Sep 13, 2013·The Cochrane Database of Systematic Reviews·Sharath Chandra Vikram ParavastuAnthony Da Silva
Dec 7, 2013·The Cochrane Database of Systematic Reviews·Deirdre A Lane, Gregory Y H Lip
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takafumi YokotaPaul W Kincade