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Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells

Cancer Prevention Research

Jul 1, 2009

Jeong-In LeeJohn Thomas Pinto

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Abstract

Histone deacetylase (HDAC) inhibitors are gaining interest as cancer therapeutic agents. We tested the hypothesis that natural organoselenium compounds might be metabolized to HDAC inhibitors in human prostate cancer cells. Se-Methyl-L-selenocysteine (MSC) and selenomethionine are amino...read more

Mentioned in this Paper

L-amino acid oxidase
Selenium supplement
Amino Acid [EPC]
Post-Translational Protein Processing
Methionine
Androgens
Organoselenium Compounds
Malignant Neoplasm of Prostate
Inhibitory Concentration 50
Prostate Carcinoma
Paper Details
References
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  • References44
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Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells

Cancer Prevention Research

Jul 1, 2009

Jeong-In LeeJohn Thomas Pinto

PMID: 19584079

DOI: 10.1158/1940-6207.capr-09-0047

Abstract

Histone deacetylase (HDAC) inhibitors are gaining interest as cancer therapeutic agents. We tested the hypothesis that natural organoselenium compounds might be metabolized to HDAC inhibitors in human prostate cancer cells. Se-Methyl-L-selenocysteine (MSC) and selenomethionine are amino...read more

Mentioned in this Paper

L-amino acid oxidase
Selenium supplement
Amino Acid [EPC]
Post-Translational Protein Processing
Methionine

Related Papers

Paper Details
References
  • References44
  • Citations34
12345
  • References44
  • Citations34
1234

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