Alpha-L-fucosidase as a tumour marker of hepatocellular carcinoma

Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology
Mohamed Fawzy MontaserMohamed Omar Khalifa

Abstract

Alphafoetoprotein (AFP) is not secreted in all cases of hepatocellular carcinoma (HCC) and may be normal in as many as 40% of patients with early HCC. Alpha-l-fucosidase (AFU), a lysosomal enzyme present in all mammalian cells, has been proposed as a tumour marker since many studies reported increased AFU serum levels in patients with cirrhosis and HCC. This study aimed at evaluation of the diagnostic value of AFU as a tumour marker of HCC and its prognostic role in follow-up after intervention. This prospective case-control study was conducted on 80 patients (40 patients with HCC and 40 patients with chronic liver disease (CLD) as diseased controls) in addition to 40 apparently healthy individuals who served as a healthy control group. AFU serum levels in the three groups were measured and compared. There was a statistically highly significant elevation (p<0.001) in the median values of serum AFU in the HCC group (0.99-26.59 μmol l(-1) min(-1)) when compared with both the CLD (0.11-4.60 μmol l(-1) min(-1)) and control (0.1-1.2 μmol l(-1) min(-1)) groups. At a cut-off value of 2.3005 μmol l(-1) min(-1), AFU yielded a sensitivity and specificity of 90% and 97.5%, respectively. In HCC patients, AFU dropped significantly after suc...Continue Reading

References

May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E ChristensenN Tygstrup
Jun 6, 2003·Biochemical and Biophysical Research Communications·Tetsuya NakatsuraYasuharu Nishimura
Mar 17, 2004·World Journal of Surgery·Ming ShiJin-Qing Li
Aug 18, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ju-Jun Wang, En-Hua Cao
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Sep 5, 2006·Cell Biology International·Irina S SmirnovaMaria G Isaguliants
Feb 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mi-Jin LeeDae-Ghon Kim
Sep 18, 2012·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mohammad A KobeisyFattahallah M Mohammad
Jul 6, 2016·Journal of the Egyptian National Cancer Institute·Dina H ZiadaHala M Elsabagh

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Citations

May 30, 2013·World Journal of Gastroenterology : WJG·Ken ChenJing Zhang
Jan 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuling GanXinghua Song
Mar 22, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Katarzyna Taranta-JanuszAnna Wasilewska
Aug 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nehad A MossadHend I Shousha
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Eman A BayomiAyman M Metwally
Nov 26, 2015·The Analyst·Eric WaidelyRoger M Leblanc
Nov 6, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hanaa H AhmedNadia S Mahmoud
Feb 23, 2018·The Analyst·Puja Sandbhor Gaikwad, Rinti Banerjee
Dec 3, 2014·The International Journal of Biological Markers·Tarek D Hussein
Sep 28, 2018·Journal of Cancer Research and Clinical Oncology·Xinyu LiXisheng Leng
Mar 22, 2014·Molecular and Clinical Oncology·Yan-Jie ZhaoGuan-Cheng Li
Oct 21, 2015·World Journal of Hepatology·Mahmoud KhattabElham Ahmed
Feb 26, 2020·PeerJ·Yameng ZhangYouhe Gao
Nov 13, 2020·Reports of Biochemistry & Molecular Biology·Olfat ShakerEngy Medhat
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza
Jul 21, 2017·Analytical Chemistry·Eric WaidelyRoger M Leblanc

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