Alpha-lactalbumin production in human mammary carcinoma.

Science
H N Rose, C M McGrath

Abstract

Alpha-Lactalbumin was isolated from mature human milk and utilized as an immunogen in rabbits. A radioimmunoassay was developed that was capable of detecting nanogram quantities of the antigen. Alpha-Lactalbumin synthesis was detected in human breast cancer cells (MCF-7) cultivated as a continuous cell line in vitro. Other human carcinoma epithelial cell lines (throat and cervix) failed to react in this assay. The ability to synthesize alpha-lactalbumin by breast carcinoma cells appeared to be independent of the addition of prolactin to the culture medium.

References

Nov 1, 1973·Journal of the National Cancer Institute·H D SouleM Brennan
May 1, 1972·European Journal of Biochemistry·J B Findlay, K Brew
Apr 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·W D PetersonW F Simpson
Dec 1, 1968·Analytical Biochemistry·N Catsimpoolas
Dec 28, 1966·Biochimica Et Biophysica Acta·D H LockwoodY J Topper
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER

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Citations

Jul 27, 1979·Journal of Cancer Research and Clinical Oncology·W E Simon, F Hölzel
Jan 1, 1992·Breast Cancer Research and Treatment·F VizosoC López-Otín
Jul 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·K L Woods, D A Heath
Jul 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·U StevensM G Ormerod
Jan 1, 1977·Journal of Immunological Methods·J Enami, S Nandi
Jun 1, 1977·Molecular and Cellular Endocrinology·B E Linebaugh, J A Rillema
Feb 1, 1989·Immunology and Cell Biology·E T Thean, B H Toh
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C K OsborneM E Lippman
Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J T EmermanS Nandi
Dec 1, 1978·International Journal of Cancer. Journal International Du Cancer·J A PetersonR L Ceriani
Sep 15, 1978·International Journal of Cancer. Journal International Du Cancer·F BalkwillJ Taylor-Papadimitriou
Mar 11, 1977·Annals of the New York Academy of Sciences·M LippmanG Bolan
Jan 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K L WoodsD A Heath
Oct 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·O Nyormoi
Sep 1, 1978·Perception & Psychophysics·D H WestendorfC Allegretti
Jul 20, 1982·Biochimica Et Biophysica Acta·B J Thompson, S Smith

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