Alpha-lipoic acid increases Na+K+ATPase activity and reduces lipofuscin accumulation in discrete brain regions of aged rats

Annals of the New York Academy of Sciences
P Arivazhagan, Chinnakkannu Panneerselvam

Abstract

A convincing link between oxidative stress and neurodegenerative diseases has been found with the knowledge that it actually damages neuronal cells in culture. We analyzed the effect of DL-alpha-lipoic acid on lipofuscin and Na(+)K(+) ATPase in discrete brain regions of young and aged rats. In aged rats, the level of lipofuscin was increased, and the activity of Na(+)K(+)ATPase was decreased. Intraperitoneal administration of lipoic acid to aged rats led to a duration-dependent reduction and elevation in lipofuscin and enzyme activity, respectively, in the cortex, cerebellum, striatum, hippocampus, and hypothalamus of the brain. These results suggest that lipoic acid, a natural metabolic antioxidant, should be useful as a therapeutic tool in preventing neuronal dysfunction in aged individuals.

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Citations

Dec 8, 2005·Biogerontology·Giovanni PaganoSeiji Kodama
Sep 25, 2012·Biogerontology·Nagwa Ibrahim ShehataAmira Abd-Elmonem Shaheen
Feb 18, 2010·American Journal of Physiology. Endocrinology and Metabolism·Virginia HaynesCecilia Giulivi
Jun 16, 2012·Neurochemical Research·Neetu SainiRajat Sandhir
Nov 8, 2014·Journal of Traditional and Complementary Medicine·Selvaraju SubashGilles J Guillemin
Feb 5, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ganesan MuraliChinnakkannu Panneerselvam
Jul 10, 2007·European Journal of Pharmacology·Ganapathy AmudhaPalaninathan Varalakshmi
Jun 29, 2006·Annals of the New York Academy of Sciences·Sorin RigaFlorin Halalau
Nov 26, 2009·Optometry : Journal of the American Optometric Association·Stuart RicherCarla Thomas
Dec 21, 2019·Journal of Biochemical and Molecular Toxicology·Shuaizeng YinChenyu Li
Oct 23, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mark L HudesBruce N Ames

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