Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats

Molecular Brain
Kang-Ho ChoiKi-Hyun Cho

Abstract

The antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects of aLA administration after the onset of ischemia. The middle cerebral artery (MCA) of adult rats was occluded for 2 hours and then reperfused. aLA (20 mg/kg) was administered in 71 animals (aLA group) through the left external jugular vein immediately after reperfusion. An equivalent volume of vehicle was administered to 71 animals (control group). Functional outcome, levels of endogenous neural precursors with neurogenesis, glial cell activation, and brain metabolism were evaluated. Immediate aLA administration after reperfusion resulted in significantly reduced mortality, infarct size, and neurological deficit score (NDS) in the test group compared to the control group. Long-term functional outcomes, measured by the rotarod test, were markedly improved by aLA treatment. There was a significant increase in the number of cells expressing nestin and GFAP in the boundary zone and infarct core regions after aLA treatment. Furthermore, significantly more BrdU/GFAP, BrdU/DCX, and BrdU/NeuN double-labeled cells were observed along the ...Continue Reading

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Citations

Apr 5, 2019·Environmental Science and Pollution Research International·Shweta ModgilAkshay Anand
Jun 19, 2015·Metabolic Brain Disease·Yan-Hua LiCun-gen Ma
Nov 10, 2018·BioMed Research International·Xiao LinLijie Huang

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