Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage

International Journal of Molecular Sciences
Dahae LeeKi Sung Kang

Abstract

Alpha (α)-mangostin, a yellow crystalline powder with a xanthone core structure, is isolated from mangosteen (Garcinia mangostana), which is a tropical fruit of great nutritional value. The aim of the present study was to investigate the anti-diabetic effects of α-mangostin and to elucidate the molecular mechanisms underlying its effect on pancreatic beta (β)-cell dysfunction. To assess the effects of α-mangostin on insulin production, rat pancreatic INS-1 cells were treated with non-toxic doses of α-mangostin (1⁻10 μM) and its impact on insulin signaling was examined by Western blotting. In addition, the protective effect of α-mangostin against pancreatic β-cell apoptosis was verified by using the β-cell toxin streptozotocin (STZ). Our results showed that α-mangostin stimulated insulin secretion in INS-1 cells by activating insulin receptor (IR) and pancreatic and duodenal homeobox 1 (Pdx1) followed by phosphorylation of phospho-phosphatidylinositol-3 kinase (PI3K), Akt, and extracellular signal regulated kinase (ERK) signaling cascades, whereas it inhibited the phosphorylation of insulin receptor substrate (IRS-1) (Ser1101). Moreover, α-mangostin was found to restore the STZ-induced decrease in INS-1 cell viability in a dose-...Continue Reading

References

Nov 17, 2001·Journal of Diabetes and Its Complications·N Abate, M Chandalia
Jul 9, 2004·The Tohoku Journal of Experimental Medicine·Omer CoskunMehmet Kanter
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lorna M Dickson, Christopher J Rhodes
Sep 15, 2004·The Journal of Biological Chemistry·Yu LiRoberto D Polakiewicz
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BugianesiGiulio Marchesini
Aug 26, 2006·Archives of Physiology and Biochemistry·Henrike SellDaniela Dietze-Schroeder
Oct 13, 2006·Cell Calcium·Guy A RutterMagalie A Ravier
Dec 5, 2006·Metabolism: Clinical and Experimental·Dominic N ReedsSamuel Klein
Jul 18, 2008·Experimental Animals·Takashi OkamotoToshiki Sudo
Sep 3, 2009·World Journal of Gastroenterology : WJG·Shinji KawahitoShuzo Oshita
Oct 17, 2009·The Journal of Biological Chemistry·Rohan K HumphreyUlupi S Jhala
Aug 10, 2011·Chinese Journal of Integrative Medicine·Pranav Kumar Prabhakar, Mukesh Doble
Oct 17, 2012·Oman Medical Journal·Abdulfatai B OlokobaLateefat B Olokoba
Jun 6, 2013·Mediators of Inflammation·Alessandra PudduFabrizio Montecucco
Jul 28, 2013·Systems Biology in Reproductive Medicine·Giri Babu NelliEswar Kumar Kilari
Jan 5, 2014·Cold Spring Harbor Perspectives in Biology·Jérémie BoucherC Ronald Kahn
Feb 15, 2014·Nature Reviews. Drug Discovery·Amedeo VetereBridget K Wagner
Aug 12, 2014·Journal of the American Pharmacists Association : JAPhA·Jennifer Dixon Smith, Valerie B Clinard
Dec 2, 2014·International Journal of Molecular Medicine·Jong Seok LeeEock Kee Hong
Jul 2, 2015·Planta medica·José Luis RíosGuillermo R Schinella
Oct 13, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sandra PereiraEvangelia Tsiani
Jun 14, 2016·Bioorganic & Medicinal Chemistry Letters·Dahae LeeKiwon Jung
Jul 23, 2016·Journal of Cellular and Molecular Medicine·Yaqin ZhangXiao Han
Apr 12, 2017·The Journal of Pharmacy and Pharmacology·Dahae LeeKi Sung Kang
Apr 18, 2017·Journal of Ginseng Research·Hye Lim Lee, Ki Sung Kang

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Citations

Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kem Ok KimKi Sung Kang
Sep 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zakiyatul FaizahDelvac Oceandy
May 22, 2020·Frontiers in Cardiovascular Medicine·Wawaimuli ArozalVivian Soetikno
Oct 18, 2020·Nutrients·Gary Williamson, Katherine Sheedy
Mar 16, 2021·Journal of Cellular and Molecular Medicine·Meng JiangMinxiang Lei
Aug 20, 2021·Future Medicinal Chemistry·Tejashri Chavan, Aaron Muth
Nov 19, 2021·Critical Reviews in Food Science and Nutrition·Yao ChenZhiyong He

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
protein assay
ELISA

Software Mentioned

SPSS

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