PMID: 8603997Feb 1, 1996Paper

alpha-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line

Journal of Leukocyte Biology
N RajoraJ M Lipton

Abstract

alpha-Melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide derived from pro-opiomelanocortin, has potent antiinflammatory activity in laboratory animals. alpha-MSH inhibits nitric oxide production by murine macrophages, an influence believed to reflect activation of an autocrine circuit in these cells, one that is based on production and release of alpha-MSH and subsequent stimulation of melanocortin receptors. We found that THP-1 cells, human monocytic cells, produced alpha-MSH; this production was increased by interleukin-6, tumor necrosis factor a, or concanavalin A. These cells also expressed the gene for the human alpha-MSH receptor MC1. Unlike murine macrophages, THP-1 cells produced little nitrite in response to interferon-gamma (IFN-gamma) and lipopolysaccharide, and a-MSH inhibited this production only slightly. However, production of neopterin, a presumed primate homologue of nitric oxide in lower animals, was increased in THP-1 cells stimulated with INF-gamma plus TNF-alpha and alpha-MSH significantly inhibited this production. The evidence indicates that an autocrine regulatory circuit based on alpha-MSH occurs in human monocyte/macrophages much as in murine macrophages. alpha-MSH-induced modulation of speci...Continue Reading

Citations

Jun 18, 1998·Annals of the New York Academy of Sciences·J M Lipton, A Catania
Jun 18, 1998·Annals of the New York Academy of Sciences·A CataniaJ M Lipton
Jan 26, 1999·Annals of the New York Academy of Sciences·A Catania, J M Lipton
Jan 9, 2004·American Journal of Respiratory and Critical Care Medicine·Jiangping DengRobert A Star
May 27, 2011·Equine Veterinary Journal. Supplement·T C HolbrookH C Schott
Feb 6, 2017·Mediators of Inflammation·Lila CarnigliaMercedes Lasaga
Oct 28, 2019·Frontiers in Endocrinology·Wei WangYa-Xiong Tao
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Delgado, D Ganea
Jun 18, 1998·Annals of the New York Academy of Sciences·T A LugerR Paus
Nov 28, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A KatsukiY Adachi
Dec 12, 2001·Clinical and Experimental Immunology·G Neumann AndersenJ E Wikberg
Feb 16, 2006·European Journal of Immunology·Sunil K MannaYashin Sreenivasan
Oct 17, 2006·Journal of Leukocyte Biology·Anna Catania
Jun 1, 2004·Pharmacological Reviews·Mario DelgadoDoina Ganea
Oct 20, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min-Duk SeoBong-Jin Lee
Mar 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Trinidad Montero-MelendezMauro Perretti
Mar 15, 1997·European Journal of Biochemistry·B LoirG Ghanem
Jul 2, 1999·Experimental Dermatology·F F Hamerlinck
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L AiraghiA Catania
Mar 28, 2001·Annals of the New York Academy of Sciences·T A LugerJ Ansel
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·Y KohdaR A Star
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S AdachiY Kitamura
Jan 24, 2013·Journal of Clinical Biochemistry and Nutrition·Keiichi HiramotoMasamitsu Ishii
Dec 1, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marcella ArciuliAnna Gallone
Mar 28, 2001·Annals of the New York Academy of Sciences·A CataniaJ M Lipton
Jul 10, 2003·Annals of the New York Academy of Sciences·Thomas A LugerMarkus Böhm
May 19, 2000·Annals of the New York Academy of Sciences·A CataniaJ M Lipton
Jan 20, 2006·Pigment Cell Research·Donald W RobertsRichard A Sturm
Jul 26, 2006·Neuroimmunomodulation·Stefano GattiAnna Catania
Dec 30, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Petteri RinneSabine Steffens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.