PMID: 19929812Nov 26, 2009Paper

alpha-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: a structure-activity relationships approach

Mini Reviews in Medicinal Chemistry
Ana I Matesanz, Pilar Souza

Abstract

alpha-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents. In this review the structural features of (N)-TSCs, required for maximum antitumour activity have been explored. Special attention is given to the mechanisms of action and structure-activity relationships.

Citations

May 6, 2015·European Journal of Medicinal Chemistry·Marcos Veríssimo de Oliveira CardosoAna Cristina Lima Leite
Nov 14, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Jia ShaoJing-Yuan Xu
Oct 21, 2016·Journal of Inorganic Biochemistry·Katarzyna BrodowskaLongin Chrusciński
Feb 25, 2018·Analytical and Bioanalytical Chemistry·Karla PelivanChristian R Kowol
Jun 24, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Ana I MatesanzPilar Souza
Oct 30, 2019·Mini Reviews in Medicinal Chemistry·Bhushan Shakya, Paras Nath Yadav
Feb 24, 2020·Journal of Inorganic Biochemistry·Raquel AlcarazCarlos García-Girón
Nov 30, 2018·Chemical Research in Toxicology·William H MorrisXiaohua Jiang

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