PMID: 7544190Jul 1, 1995Paper

alpha-Phenyl N-tert-butyl nitrone (PBN) increases the cortical cerebral blood flow by inhibiting the breakdown of nitric oxide in anesthetized rats

Free Radical Research
O Inanami, M Kuwabara

Abstract

The effects of intravenous administration of alpha-phenyl N-tert-butyl nitrone (PBN) on cortical cerebral blood flow (CBF) were examined in Wistar rats under pentobarbital anesthesia and artificial ventilation. The cortical CBF in parietal cortex was measured by laser Doppler flowmetry. Intravenous administrations of 2 mg/kg and 20 mg/kg of PBN dose-dependently produced significant increases in cortical CBF and decreases in systemic blood pressure (BP). To examine whether these increased responses in cortical CBF produced by PBN were associated with the vasodilatation system of nitric oxide (NO), the NO synthase inhibitor L-NG-nitroarginine (L-NOArg), which is an analog of L-arginine, was used to inhibit the NO-related-vasodilatative system. Since the PBN-induced responses in the cortical CBF were much attenuated in L-NOArg-treated rats (30 mg/kg, i.v.), it was inferred that NO-related vasodilatation was strongly associated with the PBN-induced increase in cortical CBF.

References

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Citations

Dec 4, 2003·Pharmacology & Therapeutics·A Richard GreenDavid M Jackson
Jun 15, 2007·Journal of the American Chemical Society·Frederick A VillamenaJay L Zweier
Mar 10, 2001·Antioxidants & Redox Signaling·Y Kotake
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Mustafa OdabaşoğluOrhan Büyükgüngör
Sep 17, 2008·Free Radical Biology & Medicine·Robert A FloydRheal A Towner
Aug 14, 2003·Fundamental & Clinical Pharmacology·Catherine VergelyLuc Rochette
Jan 29, 2000·The Journal of Thoracic and Cardiovascular Surgery·S M LangleyR M Ungerleider
Mar 12, 2008·The Journal of Organic Chemistry·Yongbin HanFrederick A Villamena

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