Alpha-smooth muscle actin containing contractile fibroblastic cells in human knee arthrofibrosis tissue. Winner of the AGA-DonJoy Award 2003

Archives of Orthopaedic and Trauma Surgery
Frank N UnterhauserAndreas Weiler

Abstract

Primary arthrofibrosis is of major concern after joint trauma or knee ligament surgery. The underlying mechanism in detail remains unclear. Highly differentiated fibroblastic cells, so-called myofibroblasts, express the actin isoform alpha-smooth muscle actin (ASMA) and have been found to play a major role in tissue contraction during wound healing and organ fibrosis. We therefore studied the expression of myofibroblasts in human primary knee arthrofibrosis tissue. Tissue samples were taken from the infrapatellar fat pad and intercondylar region of nine patients who underwent revision surgery due to arthrofibrosis after anterior cruciate ligament (ACL) reconstruction (study group). Control tissue was taken from five patients who underwent primary ACL reconstruction (control group I) and from eight patients, who underwent second-look arthroscopy after primary ACL reconstruction (control group II). ASMA containing fibroblasts were immunostained with a monoclonal antibody. Histomorphometry was performed for total cell amount, ASMA containing fibroblasts, and vessel cross-sections. The arthrofibrosis group showed a tenfold higher amount of ASMA containing myofibroblasts (23.4% vs. 2.3%) than in control group I. There was a signific...Continue Reading

References

Dec 1, 1992·The Journal of Cell Biology·M B Sporn, A B Roberts
Sep 1, 1992·The American Journal of Sports Medicine·C D HarnerF H Fu
Jul 1, 1992·The Journal of Clinical Investigation·W A Border, E Ruoslahti
Mar 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O SkalliL Orci
Dec 1, 1988·Experimental and Molecular Pathology·D OdaR Stern
Apr 1, 1972·The Journal of Experimental Medicine·G GabbianiG Majno
Jan 1, 1995·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·P AgliettiG Zaccherotti
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Jul 1, 1994·The American Journal of Sports Medicine·L E PaulosA E Greenwald
May 1, 1994·Differentiation; Research in Biological Diversity·J M EstesG Gabbiani
Mar 1, 1994·The American Journal of Sports Medicine·A J CosgareaJ E Lovelock
Mar 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A FaryniarzM Spector
Jan 1, 1997·The American Journal of Sports Medicine·K D Shelbourne, R V Trumper
Jan 1, 1996·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·H P LobenhofferT G Gerich
Jun 1, 1997·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·P P MarianiE Adriani
Mar 21, 1998·The American Journal of Surgical Pathology·W SchürchG Gabbiani
Sep 15, 1998·The Journal of Surgical Research·T S AtkinsonR C Haut
May 1, 1999·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·K D Shelbourne, D V Patel
Jul 22, 1999·Experimental Cell Research·G Serini, G Gabbiani
Aug 14, 1999·Archives of Orthopaedic and Trauma Surgery·J ZeichenU Bosch
Jul 31, 2001·The American Journal of Sports Medicine·K FukushimaJ Huard
Oct 31, 2001·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·U BoschM van Griensven
Mar 29, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Andreas WeilerNorbert P Haas

❮ Previous
Next ❯

Citations

Jan 21, 2010·Operative Orthopädie und Traumatologie·Denise Freiling, Philipp Lobenhoffer
Jan 10, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·M DustmannS U Scheffler
Jun 3, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·S U SchefflerA Weiler
Sep 28, 2012·Sports Health·Cale A Jacobs, Aaron D Sciascia
Nov 7, 2012·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Franz ChristanellHannu Luomajoki
Sep 3, 2011·The Journal of Orthopaedic and Sports Physical Therapy·A J YenchakJames R Andrews
Aug 29, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Rob P A Janssen, Sven U Scheffler
Feb 19, 2016·Journal of Orthopaedic Surgery and Research·Franz Xaver KoeckRainer H Straub
Apr 19, 2013·Revista española de cirugía ortopédica y traumatología·R Sánchez Hidalgo, F Forriol
Mar 25, 2009·Clinics in Sports Medicine·Annunziato Amendola, Mary P Stolley
Dec 12, 2007·The Journal of Hand Surgery·Anneluuk L C Lindenhovius, Jesse B Jupiter
Nov 14, 2006·Hand Clinics·Steve K LeeMichael R Hausman
Nov 7, 2015·Der Orthopäde·I J BankeH Gollwitzer
Feb 22, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Pen-hsiu Grace ChaoWei-Ren Chang
Oct 6, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·J JiangJ V Luck
Oct 21, 2016·JBJS Reviews·Basem Attum, William Obremskey
Nov 11, 2015·Scientific Reports·Nicole AbdulLee A Borthwick
Mar 14, 2017·The Journal of Arthroplasty·Victor A CheuyJennifer E Stevens-Lapsley
Jan 9, 2015·The Bone & Joint Journal·J M HallerE N Kubiak
Apr 4, 2018·JBJS Reviews·Erik ZachwiejaNeil Sheth
Sep 20, 2018·Muscle & Nerve·Chelsey L DunhamSpencer P Lake
Jan 19, 2019·Archives of Orthopaedic and Trauma Surgery·Hermann O MayrAmelie Stoehr
Jun 5, 2019·Proceedings of the National Academy of Sciences of the United States of America·William A BlessingAra Nazarian
Jun 25, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hannah L PaishNicholas S Kalson
Nov 9, 2007·The Journal of the American Academy of Orthopaedic Surgeons·David MagitMichael J Medvecky
Apr 3, 2019·Bone Research·Kayley M UsherJiake Xu
May 5, 2016·The Bone & Joint Journal·J R DonaldsonJ Gollish
Nov 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Keerthi AtluriJames A Martin
Oct 11, 2020·International Journal of Molecular Sciences·Gilberto Y NakamaJohnny Huard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved