Alpha-Synuclein in the Gastrointestinal Tract as a Potential Biomarker for Early Detection of Parkinson's Disease.

International Journal of Molecular Sciences
Dominika FricovaAlzbeta Kralova Trancikova

Abstract

The primary pathogenesis associated with Parkinson's disease (PD) occurs in peripheral tissues several years before the onset of typical motor symptoms. Early and reliable diagnosis of PD could provide new treatment options for PD patients and improve their quality of life. At present, however, diagnosis relies mainly on clinical symptoms, and definitive diagnosis is still based on postmortem pathological confirmation of dopaminergic neuronal degeneration. In addition, the similarity of the clinical, cognitive, and neuropathological features of PD with other neurodegenerative diseases calls for new biomarkers, suitable for differential diagnosis. Alpha-synuclein (α-Syn) is a potential PD biomarker, due to its close connection with the pathogenesis of the disease. Here we summarize the currently available information on the possible use of α-Syn as a biomarker of early stages of PD in gastrointestinal (GI) tissues, highlight its potential to distinguish PD and other neurodegenerative diseases, and suggest alternative methods (primarily developed for other tissue analysis) that could improve α-Syn detection procedures or diagnostic methods in general.

References

Nov 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Jan 1, 1989·Archives of Histology and Cytology·K WakabayashiF Ikuta
Aug 28, 1997·Nature·M G SpillantiniM Goedert
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniM Goedert
Jan 7, 2000·The American Journal of Pathology·W J Schulz-SchaefferH A Kretzschmar
Apr 5, 2001·Journal of Molecular Biology·D EliezerG Browne
Apr 19, 2002·Brain : a Journal of Neurology·Hirohisa WatanabeGen Sobue
Oct 25, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·A SchragN Quinn
Apr 30, 2003·The Journal of Biological Chemistry·Julie L WebbDavid C Rubinsztein
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Oct 7, 2003·Neuromolecular Medicine·Benoit I GiassonJohn Q Trojanowski
Nov 1, 2003·Science·A B SingletonK Gwinn-Hardy
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·He-Jin LeeSeung-Jae Lee
Sep 29, 2004·Lancet·Marie-Christine Chartier-HarlinAlain Destée
Jul 19, 2005·Annual Review of Neuroscience·Darren J MooreTed M Dawson
Sep 1, 2005·Current Neurology and Neuroscience Reports·Dag AarslandClive Ballard
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Charyl Del MarVirgil L Woods
Nov 1, 2005·Parkinsonism & Related Disorders·Phil Hyu LeeHeung Soo Kim
Mar 2, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Omar M A El-AgnafDavid Allsop
May 23, 2006·Lancet Neurology·Lonneke M L de Lau, Monique M B Breteler
Feb 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael L Kramer, Walter J Schulz-Schaeffer
Jul 10, 2007·The FEBS Journal·David R Brown
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
Apr 4, 2008·Brain : a Journal of Neurology·S S O'SullivanA J Lees
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J B Furness
Apr 12, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Denise M KayHaydeh Payami
Jun 21, 2008·The Journal of Biological Chemistry·Tereza VogiatziLeonidas Stefanis
Jun 27, 2009·Science·Marco SardielloAndrea Ballabio
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eunsung JunnM Maral Mouradian
Aug 29, 2009·The European Journal of Neuroscience·Thibaud LebouvierPascal Derkinderen
Nov 27, 2009·Parkinsonism & Related Disorders·Ann B SollingerStewart A Factor
Jan 29, 2010·The Journal of Biological Chemistry·Epaminondas Doxakis
Mar 23, 2010·Acta Neuropathologica·Thomas G BeachUNKNOWN Arizona Parkinson's Disease Consortium
Jun 5, 2010·Brain Pathology·Dag Aarsland, Martin Wilhelm Kurz
Aug 11, 2010·Archives of Neurology·Lydia Alvarez-ErvitiAnthony H V Schapira
Sep 14, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Maria Graciela CersósimoEduardo Elias Benarroch

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
transgenic
biopsies
biopsy
proximity ligation assay
ELISA

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.