Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis.

Alzheimer Disease and Associated Disorders
Ioannis MavroudisDimitrios Kazis

Abstract

Lewy body dementia (LBD) is the second most common type of neurodegenerative dementia after Alzheimer disease (AD). It is characterized by the accumulation of Lewy bodies and Lewy neurites which are composed of aggregated phosphorylated alpha-synuclein, which is a presynaptic neuronal protein genetically and neuropathologically linked to Parkinson disease and to LBD. Alpha-synuclein is thought to contribute to LBD pathogenesis and to linked to disruption of cellular homeostasis and neuronal death, through effects on various intracellular targets, including synaptic function. In the present study, we did a meta-analysis on the reliability of alpha-synuclein levels in the cerebrospinal fluid (CSF) for the discrimination between LBD and other neurodegenerative disorders including AD, Parkinson disease (PD) dementia, progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and frontotemporal dementia (FTD). CSF alpha-synuclein levels were significantly different in LBD compared with AD, but no statistical difference was found between LBD, and dementia in PD, MSA, PSP, and FTD. Alpha-synuclein levels in the CSF can be used for the discrimination between LBD and AD, but not LBD and other neurodegenerative disorders such as...Continue Reading

References

Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Nov 22, 2008·Neuroscience Letters·Annika OhrfeltHenrik Zetterberg
Feb 18, 2009·Journal of Alzheimer's Disease : JAD·Petra E SpiesMarcel M Verbeek
Feb 8, 2011·Journal of Alzheimer's Disease : JAD·Brit MollenhauerMirko Bibl
Dec 31, 2011·Journal of Alzheimer's Disease : JAD·Malin WennströmHenrietta M Nielsen
Feb 23, 2012·Cold Spring Harbor Perspectives in Medicine·Leonidas Stefanis
Oct 12, 2012·International Journal of Alzheimer's Disease·Kensaku KasugaTakeshi Ikeuchi
Nov 28, 2012·Nature Reviews. Neurology·Michel GoedertHeiko Braak
Dec 4, 2012·Experimental Neurology·Douglas G WalkerUNKNOWN Arizona Parkinson Disease Consortium
Jan 21, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sylvie SlaetsSebastiaan Engelborghs
Oct 6, 2015·Alzheimer's Research & Therapy·Malin WennströmOskar Hansson
Apr 1, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Min ShiJing Zhang
Nov 16, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Inger van SteenovenOmar M A El-Agnaf

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