Alpha thalassaemia in an Italian population

British Journal of Haematology
C VelatiG Fiorelli

Abstract

The incidence of alpha-thalassaemia in an Italian population has been determined by a survey of random cord bloods for the presence of Hb Bart's. 144 out of 4730 (3%) had detectable amounts of Hb Bart's. Furthermore, alpha-globin gene analysis of 100 random cord bloods showed that five out of 100 had the common type of alpha-thalassaemia caused by a single alpha-globin gene deletion (-alpha). The molecular basis of alpha-thalassaemia was also determined in a selected group of 34 newborns with detectable levels of Hb Bart's. 25 of these cases had the -alpha 3.7 deletion type of alpha-thalassaemia and nine had nondeletion types of alpha-thalassaemia in four of which the molecular defect was detectable directly by restriction enzyme analysis.

References

Dec 1, 1978·Journal of Medical Genetics·A CaoM A Melis
Feb 1, 1975·British Journal of Haematology·M E PembreyR P Perrine
Dec 1, 1983·Journal of Medical Genetics·R GalanelloA Cao
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S H OrkinR L Hechtman
May 1, 1981·European Journal of Biochemistry·L del SennoF Conconi
Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·D J Weatherall
Nov 1, 1980·British Journal of Haematology·D R HiggsD J Weatherall

❮ Previous
Next ❯

Citations

May 1, 1992·British Journal of Haematology·D K BowdenD R Higgs
Jun 29, 2000·Baillière's Clinical Haematology·J FlintJ B Clegg
Oct 1, 1989·British Journal of Haematology·M A de las NievesF Garrido
Mar 1, 1993·Baillière's Clinical Haematology·J FlintJ B Clegg
May 29, 2010·Orphanet Journal of Rare Diseases·Cornelis L Harteveld, Douglas R Higgs
Jan 1, 1992·Hemoglobin·A VillegasE Sal del Rio
Aug 1, 1995·American Journal of Hematology·A VillegasM Lozano
Apr 10, 2002·Hemoglobin·Nélida I NogueraAngela C Milani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.