PMID: 16370488Dec 24, 2005

Alpha-thalassemia among tribal populations of Eastern India

Hemoglobin
Rinini SenSarthak Sengupta

Abstract

Five hundred and thirteen unrelated subjects belonging to various tribes of West Bengal, Arunachal Pradesh and Assam in Eastern India, were screened for the presence of alpha-thalassemia (thal) gene deletion(s) as a possible cause of unexplained anemia (Hb < 11 g/dL and/or MCH <28 pg, MCV < 78 fL). As reported earlier, beta-globin gene mutant alleles were found with a frequency of up to 20% in some tribes. In the present study, alpha-globin gene deletion alleles were found in 18% of subjects from West Bengal, 3.9% from Arunachal Pradesh and 3.84% from Assam tribesmen. Coexistence of alpha- and beta-globin gene abnormalities was observed in up to 18% of some tribal groups. The high inbreeding rate and lack of appropriate medical care make these populations particularly vulnerable.

References

Jul 1, 1997·International Journal of Hematology·M DeGeeta Talukder
Jan 23, 2002·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·S K Das, Geeta Talukder
Dec 12, 1959·Nature·K BETKEI SCHLICHT
Feb 3, 2004·American Journal of Hematology·Bani GajraGeeta Talukder

Citations

Feb 8, 2013·European Journal of Clinical Nutrition·H P S Sachdev, T Gera
Mar 6, 2010·Platelets·Harris V K Naina, Samar Harris
Jul 26, 2014·Journal of Community Genetics·Rachana NagarRajiva Raman
Jun 1, 2016·The Indian Journal of Medical Research·Somphon PharephanLuksana Makonkawkeyoon
Dec 2, 2010·Genetic Testing and Molecular Biomarkers·Rinini DastidarMadhusnata De

Related Concepts

Consanguinous Mating
Genetic Equilibrium
Genetic Screening Method
Globin
Alpha-Thalassemia
Genetic Epidemiology
Tribes

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.