Alpha-tocopherol and ascorbic acid administration prevents the impairment of brain energy metabolism of hyperargininemic rats.

Cellular and Molecular Neurobiology
Débora DelwingAngela Terezinha de Souza Wyse

Abstract

1. We have previously demonstrated that arginine administration induces oxidative stress and compromises energy metabolism in rat hippocampus. In the present study we initially investigated the influence of pretreatment with alpha-tocopherol and ascorbic acid on the effects produced by arginine on hippocampus energy metabolism. We also tested the effect of acute administration of arginine on various parameters of energy metabolism, namely glucose uptake, lactate release and on the activities of succinate dehydrogenase, complex II and cytochrome c oxidase in rat cerebellum, as well as the influence of pretreatment with alpha-tocopherol and ascorbic acid on the effects elicited by arginine on this structure. 2. Sixty-day-old female Wistar rats were treated with a single i.p. injection of saline (control) or arginine (0.8 g/kg) and were killed 1 h later. In another set of experiments, the animals were pretreated for 1 week with daily i.p. administration of saline (control) or alpha-tocopherol (40 mg/kg) and ascorbic acid (100 mg/kg). Twelve hours after the last injection of the antioxidants the rats received one i.p. injection of arginine (0.8 g/kg) or saline and were killed 1 h later. 3. Results showed that arginine administratio...Continue Reading

References

Jul 1, 1979·Pediatric Research·S D CederbaumG I Sugarman
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T D OuryJ D Crapo
Jul 21, 1992·European Journal of Pharmacology·R R Trifiletti
Feb 1, 1991·Biochemical Medicine and Metabolic Biology·J C DutraC M Wannmacher
Nov 29, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·J C FischerA J Janssen
Feb 11, 1988·Nature·E O Feigl
Jan 1, 1995·Life Sciences·A C Bowling, M F Beal
May 1, 1995·Journal of Neurochemistry·W F Maragos, F S Silverstein
Dec 1, 1994·Journal of Cardiovascular Pharmacology·A MüggeP R Lichtlen
Jul 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·P RustinA Munnich
Jun 1, 1996·Journal of Chemical Neuroanatomy·V L Dawson, T M Dawson
Jun 6, 1998·Journal of Applied Physiology·N Bitterman, H Bitterman
Aug 1, 1998·Journal of Inherited Metabolic Disease·R IyerS Cederbaum
Mar 17, 1999·Biochimica Et Biophysica Acta·S J HealesJ B Clark
Jan 5, 2001·Nitric Oxide : Biology and Chemistry·I T DemchenkoC A Piantadosi
Aug 23, 2001·Brain Research. Brain Research Reviews·R D'Hooge, P P De Deyn
Aug 2, 2002·Neuroreport·Débora DelwingAngela T S Wyse
Apr 30, 2003·Neurochemical Research·Caren S BavarescoAngela T S Wyse
Aug 14, 2003·Brain Research·Débora DelwingAngela Terezinha de Souza Wyse
Apr 6, 2004·Biochimica Et Biophysica Acta·Govind T VatasseryHung T Quach
Apr 6, 2004·Experimental Brain Research·Jean-Sébastien BlouinJacques Paillard
Oct 7, 2004·Neurobiology of Learning and Memory·Larry R Squire

❮ Previous
Next ❯

Citations

Jul 6, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daniela Delwing-de LimaDébora Delwing-Dal Magro
Jan 8, 2011·Fundamental & Clinical Pharmacology·Daniela Delwing de LimaDébora Delwing-Dal Magro
Mar 1, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Francieli M StefanelloAngela T S Wyse
Jan 2, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daniela DelwingAngela T S Wyse
Jan 20, 2007·Metabolic Brain Disease·Débora DelwingAngela T S Wyse
May 23, 2007·Metabolic Brain Disease·Débora DelwingAngela T S Wyse
Nov 19, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Karine Louize VincenziDaniela Delwing-de Lima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.