Alpha-tocopherol as a modulator of smooth muscle cell proliferation

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Angelo AzziA Tasinato

Abstract

The effects of alpha-tocopherol and beta-tocopherol have been studied in rat and human aortic smooth muscle cells. Alpha-tocopherol, but not beta-tocopherol, inhibited smooth muscle cell proliferation and protein kinase C in a dose-dependent manner, at concentrations ranging from 10 to 50 microM. Beta-tocopherol added simultaneously with alpha-tocopherol prevented both proliferation and protein kinase C inhibition. Protein kinase C inhibition was cell cycle-dependent and it was prevented by okadaic acid, a protein phosphatase inhibitor. Protein kinase C activity measured from aortas of cholesterol-fed rabbits was also inhibited by alpha-tocopherol. By using protein kinase C (PKC) isoform-specific inhibitors and immunoprecipitation reactions it was found that PKC-alpha was selectively inhibited by alpha-tocopherol. Further, an activation of protein phosphatase 2A by alpha-tocopherol was found, which caused PKC-alpha dephosphorylation and inhibition. Ultimately, this cascade of events at the level of cell signal transduction leads to the inhibition of smooth muscle cell proliferation.

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Citations

Aug 25, 2001·Journal of Physiology and Biochemistry·E Herrera, C Barbas
Apr 20, 2001·British Journal of Pharmacology·N VacaresseA Negre-Salvayre
Mar 7, 2001·Antioxidants & Redox Signaling·J M Villalba, P Navas
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Mar 14, 2014·Redox Biology·Maria WallertStefan Lorkowski
Oct 29, 2002·Journal of Lipid Research·Dawn C SchwenkeMichael J Thomas
Apr 8, 2020·Oxidative Medicine and Cellular Longevity·Ricardo Raúl Robles-RiveraAdolfo Daniel Rodríguez-Carrizalez
Sep 13, 2019·Journal of Diabetes Research·Olvera-Montaño CeciliaRodríguez-Carrizalez Adolfo Daniel
Oct 28, 1999·The American Journal of Clinical Nutrition·G T VatasseryM Dysken

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