PMID: 11323119Apr 27, 2001Paper

Alpha-tocopherol controls cell proliferation in the adult rat dentate gyrus

Neuroscience Letters
Riccardo CuppiniStefano Papa

Abstract

The effect of alpha-tocopherol on cell proliferation and proliferated cell survival was investigated in the dentate gyrus of adult rats. Adult rats were supplemented with alpha-tocopherol, injected with 5-bromo-2'-deoxyuridine (BrdU), that is incorporated into DNA during the S-phase, and killed at different time after BrdU injection. The number of newborn cells decreased after alpha-tocopherol supplementation, confirming the hypothesis that alpha-tocopherol is able to depress cell proliferation in vivo. Most newborn cells die within few days; more newborn cells survive in alpha-tocopherol-treated rats, suggesting the hypothesis that alpha-tocopherol decreases cell death.

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Citations

Aug 16, 2006·The Journal of Membrane Biology·Waleed B Alshuaib, Mini V Mathew
Dec 17, 2016·International Journal of Molecular Sciences·Patrizia AmbroginiAndrea Minelli
Aug 5, 2003·Journal of Neuroscience Research·Tiziana CecchiniPaolo Del Grande
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Taku NagaiToshitaka Nabeshima

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