PMID: 8958143Jan 1, 1997Paper

alpha-tocopherol enrichment of high-density lipoproteins: stabilization of hydroperoxides produced during copper oxidation

Free Radical Biology & Medicine
C LaureauxJ Delattre

Abstract

In the aim to study the effect of an in vitro enrichment of high-density lipoprotein (HDL) with alpha-tocopherol in alcoholic solution on a copper-induced peroxidation, we monitored several markers of lipid peroxidation (alpha-tocopherol consumption, formation of conjugated dienes and of fatty acid hydroperoxides, production of thiobarbituric acid-reactive substances) and the integrity of apolipoprotein A-I. High-density lipoproteins (1.063 < d < 1.21) with a mean of 0.58 alpha-tocopherol molecules per HDL particle were enriched with alpha-tocopherol in alcoholic solution to obtain an average of 3.7 and 21 alpha-tocopherol molecules per HDL particle. HDL oxidation with 5 microM CuSO4 at 37 degrees C resulted in the total disappearance of endogenous alpha-tocopherol after 2 h, but after 24 h about 19% of alpha-tocopherol remained in the most enriched HDL. In agreement with the tocopherol-mediated peroxidation, the formation of conjugated dienes and of fatty acid hydroperoxides was very fast and increased with alpha-tocopherol concentration, whereas TBARS production decreased. These results showed that alpha-tocopherol enrichment stabilized the production of hydroperoxides in HDL and decreased the formation of secondary oxidation...Continue Reading

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Citations

Dec 1, 2001·Free Radical Biology & Medicine·O RavehD Lichtenberg
Mar 15, 2008·Redox Report : Communications in Free Radical Research·Maliheh HajianiParvin Pasalar
Sep 25, 2010·Lipids in Health and Disease·Nakanishi ShuheiMarja-Riitta Taskinen
Jan 5, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·D Bonnefont-RousselotJ Delattre
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Jan 5, 2006·Free Radical Research·Natasa StojanovićJanko N Herak
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Jul 1, 2011·The Journal of Nutritional Biochemistry·Nida NadeemJane McEneny

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