Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group

Neurology
G T VatasseryM A Kuskowski

Abstract

Alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76+/-10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.

Citations

Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Peter A LeWitt, Danette C Taylor
Dec 12, 2001·Neurochemistry International·Stephen C BondyDebomoy K Lahiri
Jun 25, 2003·Toxicology·Marc W Fariss, Jin-Gang Zhang
Jul 11, 2002·Free Radical Biology & Medicine·Christian Behl, Bernd Moosmann
Oct 8, 1999·Journal of the American College of Nutrition·K N PrasadB Kumar
May 14, 2005·Antioxidants & Redox Signaling·Clifford W Shults
Oct 6, 2010·Orphanet Journal of Rare Diseases·Noel PerettiUNKNOWN Department of Pediatrics, CHU Sainte-Justine Research Center, Université de Montréal
Jun 4, 2008·American Journal of Veterinary Research·Jamie K HigginsNicola Pusterla
Dec 19, 2013·Journal of Inherited Metabolic Disease·Leslie MatalongaAntonia Ribes
Oct 22, 2002·Expert Opinion on Investigational Drugs·Bernd Moosmann, Christian Behl
Mar 9, 2005·Annals of the New York Academy of Sciences·Chandan K SenSashwati Roy
Oct 19, 2002·Nutritional Neuroscience·A V Rao, B Balachandran
Jun 24, 2017·Antioxidants & Redox Signaling·Maria Valeria CataniMauro Maccarrone
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Jul 10, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Ariel Fangting YingLouis C S Tan
Oct 28, 1999·The American Journal of Clinical Nutrition·G T VatasseryM Dysken
Mar 28, 2019·Oxidative Medicine and Cellular Longevity·Xiuzhen ZhaoYing Zhang
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine A McCaryJoan M Cook-Mills
May 5, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·UNKNOWN Alsuntangled Group, Bedlack Richard
Aug 31, 2021·RSC Medicinal Chemistry·Maximillian Taro William LeeMark David Rackham
Jun 15, 2005·Journal of Proteome Research·Lidija JerkovicHans Dieplinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.