PMID: 8598549Mar 1, 1996Paper

alpha-Tocopherol influences in vivo indices of lipid peroxidation in postmenopausal women given fish oil

The Journal of Nutrition
R C WanderK E Rowe

Abstract

Although diets containing fish have been shown to be therapeutically valuable, the vitamin E requirement when large quantities of (n-3) fatty acids are consumed is not known. Additionally, as estrogens may function as an antioxidant, the requirement may be modified in postmenopausal women using hormone replacement therapy (HRT). Consequently, the purpose of this study was to measure the impact of graduated doses of RRR-alpha-tocopheryl acetate (TA) on in vivo indices of lipid peroxidation in postmenopausal women with and without hormone replacement therapy when given a supplement of fish oil. Forty-eight postmenopausal women, half receiving (+HRT) and half not receiving (-HRT) hormone replacement therapy, participated in a four-period, double-blind crossover trial. Each period lasted 5 wk followed by a 4-wk washout interval. During each period, the subjects consumed a 15-g supplement of fish oil and either 0, 100, 200, or 400 mg TA/d in a balanced, single square dosing order. Plasma levels of (n-3) fatty acids were significantly higher after fish oil supplementation; alpha-tocopherol concentration of plasma was significantly higher at each level of supplementation compared with the level without supplementation. Urinary excreti...Continue Reading

Citations

Mar 30, 1999·The Proceedings of the Nutrition Society·D Wu, S N Meydani
Mar 1, 2016·European Journal of Nutrition·Yang ZhaoEileen R Gibney
Jun 28, 2003·American Journal of Veterinary Research·Jean A HallRosemary C Wander
Aug 5, 2003·Journal of the American College of Nutrition·Lisa G WoodManohar L Garg
Aug 27, 1999·Scandinavian Journal of Clinical and Laboratory Investigation·T FoulonA Hadjian
Oct 3, 2013·Expert Opinion on Investigational Drugs·Kuan-Pin SuChi-Un Pae
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M Papas
Jul 16, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hasan ErdoganOzge Ardicoglu
Oct 17, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R C WanderD R Thomas
Feb 9, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lisa G WoodManohar L Garg

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