alpha-Tocopherol protects against alpha-naphthylisothiocyanate-induced hepatotoxicity in rats less effectively than melatonin

Chemico-biological Interactions
Y OhtaKazuo Yamada

Abstract

The protective effect of alpha-tocopherol (alpha-Toc), which exerts antioxidant and anti-inflammatory actions, against alpha-naphthylisothiocyanate (ANIT)-induced hepatotoxicity in rats was compared with that of melatonin because orally administered melatonin is known to protect against ANIT-induced hepatotoxicity in rats through its antioxidant and anti-inflammatory actions. Rats intoxicated once with ANIT (75 mg/kg, intraperitoneal (i.p.)) showed liver cell damage and biliary cell damage with cholestasis at 24 h, but not 12 h, after intoxication. ANIT-intoxicated rats received alpha-Toc (100 or 250 mg/kg) or melatonin (100 mg/kg) orally at 12 h after intoxication. The alpha-Toc administration protected against liver cell damage in ANIT-intoxicated rats, while the melatonin administration protected against both liver cell damage and biliary cell damage with cholestasis. ANIT-intoxicated rats had increased hepatic lipid peroxide concentration and myeloperoxidase activity at 12 and 24 h after intoxication. ANIT-intoxicated rats also had increased serum alpha-Toc and non-esterified fatty acid (NEFA) concentrations at 12 and 24 h after intoxication and increased serum triglyceride and total cholesterol concentrations at 24h. The a...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Apr 1, 1976·Biochemical Medicine·K Yagi
Jan 1, 1975·Journal of Nutritional Science and Vitaminology·K AbeG Katsui
Jan 1, 1992·The International Journal of Biochemistry·T StelmaszyńskaR J Schaur
May 1, 1990·Journal of Pharmacological Methods·C SchierwagenC Lundberg
Jan 1, 1990·Life Sciences·D L DuvalR E Billings
Jul 15, 1983·Analytical Biochemistry·K SuzukiT Fujikura
Apr 1, 1981·Lipids·G S SundaramP Goldstein
May 1, 1994·Journal of Pineal Research·C S ShidaM T Lamy-Freund
Jan 1, 1994·Life Sciences·C PieriF Marcheselli
Jan 1, 1993·Critical Reviews in Toxicology·D C Liebler
Feb 1, 1997·Drug Metabolism Reviews·R A Roth, L J Dahm
Aug 1, 1997·The American Journal of Physiology·J J ZimmermanJ Lewandoski
Sep 20, 1997·British Journal of Clinical Pharmacology·H SeegarT H Lippert
Feb 18, 1998·Toxicology and Applied Pharmacology·D A Hill, R A Roth
Mar 13, 1998·Life Sciences·B LongoniP L Marchiafava
Dec 5, 1998·Biochimica Et Biophysica Acta·L Y ZangV Vallyathan
Feb 27, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·D A HillR A Roth
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D X TanR J Reiter
Nov 17, 2001·European Journal of Pharmacology·C M LotufoR P Markus
Dec 18, 2002·Journal of Pineal Research·M AllegraM A Livrea
Dec 18, 2002·Journal of Pineal Research·Dun-Xian TanRussel J Reiter
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·David RocksénAnders Bucht
Nov 6, 2003·Redox Report : Communications in Free Radical Research·Anna-Rebekka RessmeyerRüdiger Hardeland
Mar 9, 2005·Annals of the New York Academy of Sciences·John K LodgeAnna R Proteggente

❮ Previous
Next ❯

Citations

May 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Tadashi NakamuraNobuhiro Harada
Apr 27, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Evan I SaadAzza E Bistawroos
Mar 24, 2017·International Journal of Molecular Sciences·Jiao-Jiao ZhangHua-Bin Li
Aug 22, 2018·International Journal of Molecular Sciences·Russel J ReiterDario Acuna-Castroviejo
Apr 25, 2019·Brazilian Journal of Biology = Revista Brasleira De Biologia·Sohair R FahmyWafaa E Abd-El Aal
Oct 13, 2017·Journal of Cellular Physiology·Keywan Mortezaee, Neda Khanlarkhani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.