Alpha-Tocopherol Serum Levels Are Increased in Caucasian Women with Uterine Fibroids: A Pilot Study

BioMed Research International
Michał CiebieraMarta Włodarczyk

Abstract

Uterine fibroids (UFs) are benign tumors of the reproductive tract, arising from smooth muscle cells of the uterus. Steroid hormones, estrogen, and progesterone are considered to be the most important links in the pathophysiology of UFs. Alpha-tocopherol (AT) is the most active form of vitamin E. What is important as far as UFs are concerned is that ATs contain structural determinants, which makes them possible ligands for estrogen receptors (ERs). We present a retrospective cohort study performed in a university teaching hospital. We included a total of 162 patients divided into 2 groups: with UFs and controls. The effects of age, body mass index (BMI), positive medical history, parity, and AT serum concentrations on the risk for the development of UFs were investigated. Mean AT serum concentrations were 11.66 ± 4.97 μg/ml and 7.83 ± 3.13 μg/ml (medians 10.56 μg/ml and 7.42 μg/ml) in patients with UFs confirmed on ultrasound and controls, respectively. The presented difference was statistically significant. Higher BMI, positive family history, and low parity were found to be major risk factors for UFs. In our study, we confirmed that elevated serum AT concentration might be an important risk factor for UFs in Caucasian women. ...Continue Reading

References

Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L BartonP Novotny
May 9, 2000·Progress in Lipid Research·A Azzi, A Stocker
Jan 28, 2003·American Journal of Obstetrics and Gynecology·Donna Day BairdJoel M Schectman
Jun 27, 2003·Environmental Health Perspectives·Gordon P FlakeDarlene Dixon
May 28, 2004·Seminars in Reproductive Medicine·Steven L YoungJohn A Copland
Mar 17, 2005·JAMA : the Journal of the American Medical Association·Eva LonnUNKNOWN HOPE and HOPE-TOO Trial Investigators
Jul 7, 2005·JAMA : the Journal of the American Medical Association·I-Min LeeJulie E Buring
Jul 22, 2006·Nutrition & Metabolism·Alison TovarSarah L Booth
Nov 9, 2006·Journal of Agricultural and Food Chemistry·Emmanuelle ReboulPatrick Borel
Feb 27, 2007·Molecular Aspects of Medicine·Attilio Rigotti
Apr 14, 2007·Fertility and Sterility·William H Parker
May 13, 2008·The Journal of Surgical Research·Elizabeth A PeraltaGary L Dunnington
Apr 9, 2010·Endocrinology·Hiroshi IshikawaTakeshi Kurita
Jun 15, 2011·Free Radical Biology & Medicine·Maret G Traber, Jan F Stevens
Jun 16, 2011·Journal of Women's Health·Chantel L MartinElizabeth F Racine
Oct 13, 2011·JAMA : the Journal of the American Medical Association·Eric A KleinLaurence H Baker
Nov 3, 2011·Journal of Occupational and Environmental Medicine·Tomasz Macioch, Tomasz Hermanowski
Nov 11, 2011·The American Journal of Clinical Nutrition·Lauren A WiseLynn Rosenberg
Dec 21, 2011·Oncotarget·Netta MäkinenLauri A Aaltonen
Jan 17, 2012·American Journal of Obstetrics and Gynecology·Eden R CardozoJames H Segars
Feb 4, 2012·Journal of Assisted Reproduction and Genetics·Nedim CicekYasemin Genc
May 10, 2012·PloS One·Masanori OnoSerdar E Bulun
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Md Soriful IslamPasquapina Ciarmela
Apr 6, 2013·Fertility and Sterility·Md Soriful IslamPasquapina Ciarmela
Oct 4, 2013·The New England Journal of Medicine·Serdar E Bulun
Nov 19, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Goran BjelakovicChristian Gluud
Oct 19, 2014·Molecular Genetics and Genomics : MGG·Sunil K HalderAyman Al-Hendy
Mar 17, 2015·American Journal of Obstetrics and Gynecology·Ahmed M SolimanCraig Winkel
Apr 17, 2015·Molecular Medicine·Mostafa A BorahayDarren Boehning
Dec 27, 2015·Pharmacology & Therapeutics·Hong Yong PehW S Fred Wong
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Miika MehineLauri A Aaltonen
Mar 17, 2016·World Journal of Biological Chemistry·Lisa SchmölzMaria Wallert
Jun 24, 2016·Nature Reviews. Disease Primers·Elizabeth A StewartBeverley Vollenhoven
Nov 23, 2016·Reproductive Sciences·Mostafa A BorahayAyman Al-Hendy
Mar 16, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·E A StewartR Schulze-Rath
May 10, 2017·Fertility and Sterility·Nicole M FletcherGhassan M Saed
Aug 2, 2017·The Lancet Oncology·Jack Cuzick
Aug 19, 2017·Oxidative Medicine and Cellular Longevity·Gabriele PizzinoAlessandra Bitto

❮ Previous
Next ❯

Citations

Aug 3, 2020·Current Opinion in Obstetrics & Gynecology·Esra CetinMichał Ciebiera
Aug 6, 2020·International Journal of Molecular Sciences·Michał CiebieraAyman Al-Hendy
Apr 17, 2019·Molecular Biology Reports·Angela T Alleyne, Virgil S Bideau

❮ Previous
Next ❯

Methods Mentioned

BETA
reversed phase chromatography
biopsies

Software Mentioned

Statistica

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.