alpha-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice

The American Journal of Clinical Nutrition
Maria S HerbasHiroshi Suzuki

Abstract

Nutritional status likely plays an important role in determining the outcome of protozoan infections. Despite the evidence of Plasmodium sensitivity to oxidative stress, the potential role of vitamin E, a free radical scavenger, on the outcome of cerebral malaria (CM) has yet to be elucidated. To determine the influence of vitamin E on Plasmodium parasite development and murine CM outcome, alpha-tocopherol transfer protein (alpha-TTP), a regulator of vitamin E in the host circulation, was abrogated. alpha-TTP knockout mice were infected with Plasmodium berghei ANKA, and survival rate, parasitemia, brain histologic alterations, and brain barrier permeability were assessed. In addition, mRNA expression of the cytokines and adhesion molecules involved in this neurologic pathology were monitored. alpha-TTP knockout mice infected with P. berghei ANKA did not exhibit any clinical or pathologic signs of CM, and a histologic analysis of the brain tissues in these animals showed no alteration of blood-brain barrier integrity compared with that in control mice. Interestingly, protection of the blood-brain barrier in these infected alpha-TTP knockout mice was lost when dietary supplementation with vitamin E was added to their diet. Moreov...Continue Reading

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Aug 22, 2009·Free Radical Biology & Medicine·Maria Shirley HerbasHiroshi Suzuki

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Citations

Feb 10, 2012·PLoS Pathogens·Alister G CraigUNKNOWN participants of the Hinxton Retreat meeting on Animal Models for Research on Severe Malaria
Dec 1, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rhea LongleyPhilippe Gros
Aug 22, 2015·PloS One·Maria Shirely HerbasHiroshi Suzuki
Dec 28, 2018·International Journal of Molecular Sciences·Hiroshi SuzukiMaria Shirely Herbas
Mar 30, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hong Ming HuangGaetan Burgio
Nov 15, 2011·The American Journal of Pathology·Norinne Lacerda-QueirozAntonio L Teixeira

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