Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis

FEBS Letters
Marco TomasettiAntonio Procopio

Abstract

We evaluated the ability of alpha-tocopheryl succinate (alpha-TOS) to sensitise TRAIL-resistant malignant mesothelioma (MM) cells to TRAIL-induced apoptosis. We show that alpha-TOS activates expression of DR4/DR5 in a p53-dependent manner and re-establishes sensitivity of resistant MM cells to TRAIL-mediated apoptosis, as documented in p53wt MM cells but not in their p53null counterparts. MM cells selected for TRAIL resistance expressed low cell surface levels of DR4 and DR5. Treatment with sub-lethal doses of alpha-TOS restored expression of DR4 and DR5. The ability of alpha-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli.

References

Jul 2, 1992·Nature·D P Lane
Jun 6, 1991·Nature·A J LevineC A Finlay
Oct 1, 1970·Journal of Cellular Physiology·R P Perry, D E Kelley
Apr 1, 1995·The Annals of Thoracic Surgery·H I PassW J Matthews
May 31, 1996·The Journal of Biological Chemistry·R M PittiA Ashkenazi
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Oct 6, 1997·The EMBO Journal·H WalczakC T Rauch
Nov 5, 1997·Nature Genetics·G S WuW S el-Deiry
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Feb 4, 1999·Nature Medicine·L E French, J Tschopp
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J NeuzilC Weber
Aug 3, 2002·Nature Reviews. Cancer·Karen H Vousden, Xin Lu
Dec 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shulin Wang, Wafik S El-Deiry
Dec 5, 2003·International Journal of Molecular Medicine·Seung Hun JangChoon-Taek Lee
Dec 10, 2003·Oncogene·Jordan S Fridman, Scott W Lowe
Mar 5, 2004·International Journal of Cancer. Journal International Du Cancer·Marco TomasettiJiri Neuzil
Aug 4, 2004·Cancer Research·Xiangguo LiuShi-Yong Sun
Aug 2, 2005·Lancet·Bruce W S RobinsonRichard A Lake
Nov 16, 2005·Nature Medicine·Anna A SablinaPeter M Chumakov

❮ Previous
Next ❯

Citations

Sep 6, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hongqin ZhuangZi-Chun Hua
Apr 21, 2011·Antioxidants & Redox Signaling·Renata ZobalovaJiri Neuzil
Apr 8, 2010·Molecular Cancer Therapeutics·Sahdeo PrasadBharat B Aggarwal
Jun 8, 2012·Cancer Cell International·Ammad Ahmad FarooqiMuhammad Ismail
Jun 16, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Kenneth W HanceJohn W Greiner
Aug 19, 2014·Trends in Pharmacological Sciences·Sahdeo PrasadBharat B Aggarwal
Sep 15, 2010·Free Radical Research·Agnieszka AugustyniakNeven Zarković
May 15, 2007·Molecular Aspects of Medicine·Jiri NeuzilStephen J Ralph
Dec 17, 2008·Molecular Nutrition & Food Research·Yan ZhaoKun Wu
May 10, 2007·The British Journal of Dermatology·J EberleE Stockfleth
Jul 2, 2008·Biochemical and Biophysical Research Communications·Renata ZobalovaJiri Neuzil
Jul 14, 2007·Vitamins and Hormones·Marco Tomasetti, Jiri Neuzil
Aug 3, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kyoung-Jin MinTaeg Kyu Kwon
Feb 15, 2008·Medicinal Research Reviews·Masami Ishibashi, Takashi Ohtsuki
May 31, 2008·International Journal of Cancer. Journal International Du Cancer·Constantina ConstantinouAndreas I Constantinou
Oct 22, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Markus WeckmannJoerg Mattes
Sep 30, 2016·Biochemistry. Biokhimii︠a︡·M A Savitskaya, G E Onischenko
Jul 28, 2009·Cancer Letters·Vanesa MartínCarmen Rodriguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis